CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028727
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine-protein kinase PINK1, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Pink1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
105IQAIFTQKTKRVSDPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 550 AA 
Protein Sequence
MAVRQALGRG LQLERPGQVV SPGAQPRPVG LPLPDRYRFF RQSVAGLAAR IQRQFMVRAR 60
GGAGPCGRAV FLAFGLGLGL IEEKQAEGRR AASACQEIQA IFTQKTKRVS DPLDTRCWQG 120
FRLEDYLIGQ AIGKGCNAAV YEATMPTLPQ HLEKAKHLGL IGKGPDVVLK GADGEQAPGT 180
PTFPFAIKMM WNISAGSSSE AILSKMSQEL VPASRVALAG EYGAVTYRRS RDGPKQLAPH 240
PNIIRVFRAF TSSVPLLPGA LADYPDMLPP HYYPEGLGHG RTLFLVMKNY PCTLRQYLEE 300
QTPSSRLATM MTLQLLEGVD HLVQQGIAHR DLKSDNILVE WDSDGCPWLV ISDFGCCLAD 360
QHVGLRLPFN SSSVERGGNG SLMAPEVSTA HSGPSAVIDY SKADTWAVGA IAYEIFGLAN 420
PFYGQGSAHL ESRSYQEAQL PEMPESVPPE ARRLVRSLLQ REASKRPSAR LAANVLHLSL 480
WGEHLLALKN LKLDKMIAWL LQQSAATLLA DRLREKSCVE TKLQMLFLAN LECEALCQAA 540
LLLSSWRAAP 550 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016301; F:kinase activity; IDA:MGI.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0033603; P:positive regulation of dopamine secretion; IMP:MGI.
 GO:0032226; P:positive regulation of synaptic transmission, dopaminergic; IMP:MGI. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS