CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002370
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glucose-6-phosphate isomerase 
Protein Synonyms/Alias
 GPI; Autocrine motility factor; AMF; Neuroleukin; NLK; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI; Sperm antigen 36; SA-36 
Gene Name
 GPI 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
51TRDPQFQKLQQWYREubiquitination[1]
112RMLVDLAKSRGVEAAubiquitination[1]
163DVMPEVNKVLDKMKSubiquitination[1]
237ITNAETAKEWFLQAAubiquitination[1]
245EWFLQAAKDPSAVAKubiquitination[1]
252KDPSAVAKHFVALSTubiquitination[1]
477LERLLPHKVFEGNRPubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons. 
Sequence Annotation
 ACT_SITE 358 358 Proton donor.
 ACT_SITE 389 389
 ACT_SITE 519 519
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 12 12 N6-acetyllysine.
 MOD_RES 109 109 Phosphothreonine.
 MOD_RES 142 142 N6-acetyllysine.
 MOD_RES 185 185 Phosphoserine; by CK2.
 MOD_RES 454 454 N6-malonyllysine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Angiogenesis; Complete proteome; Cytokine; Cytoplasm; Direct protein sequencing; Disease mutation; Gluconeogenesis; Glycolysis; Growth factor; Hereditary hemolytic anemia; Isomerase; Phosphoprotein; Polymorphism; Reference proteome; Secreted; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 558 AA 
Protein Sequence
MVALCSLQHL GSSDPRALPT LPTATSGQRP AKRRRKSPAM AALTRDPQFQ KLQQWYREHR 60
SELNLRRLFD ANKDRFNHFS LTLNTNHGHI LVDYSKNLVT EDVMRMLVDL AKSRGVEAAR 120
ERMFNGEKIN YTEGRAVLHV ALRNRSNTPI LVDGKDVMPE VNKVLDKMKS FCQGPLMVTE 180
ALKPYSSGGP RVWYVSNIDG THIAKTLAQL NPESSLFIIA SKTFTTQETI TNAETAKEWF 240
LQAAKDPSAV AKHFVALSTN TTKVKEFGID PQNMFEFWDW VGGRYSLWSA IGLSIALHVG 300
FDNFEQLLSG AHWMDQHFRT TPLEKNAPVL LALLGIWYIN CFGCETHAML PYDQYLHRFA 360
AYFQQGDMES NGKYITKSGT RVDHQTGPIV WGEPGTNGQH AFYQLIHQGT KMIPCDFLIP 420
VQTQHPIRKG LHHKILLANF LAQTEALMRG KSTEEARKEL QAAGKSPEDL ERLLPHKVFE 480
GNRPTNSIVF TKLTPFMLGA LVAMYEHKIF VQGIIWDINS FDQWGVELGK QLAKKIEPEL 540
DGSAQVTSHD ASTNGLINFI KQQREARVQ 569 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0004347; F:glucose-6-phosphate isomerase activity; TAS:Reactome.
 GO:0016866; F:intramolecular transferase activity; IEA:Compara.
 GO:0048029; F:monosaccharide binding; IEA:Compara.
 GO:0046185; P:aldehyde catabolic process; IEA:Compara.
 GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
 GO:0006094; P:gluconeogenesis; TAS:Reactome.
 GO:0051156; P:glucose 6-phosphate metabolic process; IEA:Compara.
 GO:0006096; P:glycolysis; TAS:Reactome.
 GO:0007599; P:hemostasis; TAS:ProtInc.
 GO:0006959; P:humoral immune response; TAS:ProtInc.
 GO:0007611; P:learning or memory; IEA:Compara.
 GO:0019242; P:methylglyoxal biosynthetic process; IEA:Compara.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 
Interpro
 IPR001672; G6P_Isomerase.
 IPR023096; G6P_Isomerase_C.
 IPR018189; Phosphoglucose_isomerase_CS. 
Pfam
 PF00342; PGI 
SMART
  
PROSITE
 PS00765; P_GLUCOSE_ISOMERASE_1
 PS00174; P_GLUCOSE_ISOMERASE_2
 PS51463; P_GLUCOSE_ISOMERASE_3 
PRINTS
 PR00662; G6PISOMERASE.