UniProt Accession

 ARFP2_HUMAN; P53365; B4DX86; B4E306; D3DQT5 

Genbank Protein ID

 U52522; AK301856; AK304512; AC084337; CH471064; CH471064; BC000392; X97567 

Genbank Nucleotide ID

 AAA97924.1; BAG63298.1; BAG65318.1; EAW68707.1; EAW68708.1; AAH00392.1; CAA66179.1 

Protein Name

 Arfaptin-2 

Protein Synonyms/Alias

 ADP-ribosylation factor-interacting protein 2; Partner of RAC1; Protein POR1 

Gene Name

 ARFIP2 

Gene Synonyms/Alias

 POR1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
226	EDTLMTVKQYEAARL	ubiquitination	[1, 2]
290	LKFLEENKIKVMHKQ	ubiquitination	[2]
334	LRPPGAEKPSWLEEQ	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling. 

Sequence Annotation

 DOMAIN 121 321 AH.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 341 AA 

Protein Sequence

Gene Ontology

 GO:0005938; C:cell cortex; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; TAS:UniProtKB.
 GO:0001726; C:ruffle; IMP:UniProtKB.
 GO:0005525; F:GTP binding; TAS:ProtInc.
 GO:0030742; F:GTP-dependent protein binding; TAS:UniProtKB.
 GO:0048365; F:Rac GTPase binding; TAS:UniProtKB.
 GO:0030036; P:actin cytoskeleton organization; IMP:UniProtKB.
 GO:0006928; P:cellular component movement; TAS:ProtInc.
 GO:0030032; P:lamellipodium assembly; TAS:UniProtKB.
 GO:0031529; P:ruffle organization; TAS:UniProtKB.
 GO:0007264; P:small GTPase mediated signal transduction; TAS:ProtInc. 

Interpro

 IPR027267; AH/BAR-dom.
 IPR010504; AH_dom. 

Pfam

 PF06456; Arfaptin 

SMART

 SM01015; Arfaptin 

PROSITE

 PS50870; AH 

PRINTS