Tag | Content |
---|
CPLM ID | CPLM-011693 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Triple functional domain protein |
Protein Synonyms/Alias | |
Gene Name | Trio |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
---|
281 | DLDLEGQKLLQRIQS | ubiquitination | [1] | 2099 | QLTDLLIKPVQRIMK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth (By similarity). |
Sequence Annotation | DOMAIN 65 210 CRAL-TRIO. REPEAT 218 338 Spectrin 1. REPEAT 340 446 Spectrin 2. REPEAT 566 672 Spectrin 3. REPEAT 673 784 Spectrin 4. REPEAT 907 1012 Spectrin 5. REPEAT 1138 1244 Spectrin 6. DOMAIN 1292 1467 DH 1. DOMAIN 1479 1591 PH 1. DOMAIN 1656 1721 SH3. DOMAIN 1969 2145 DH 2. DOMAIN 2157 2271 PH 2. DOMAIN 2688 2778 Ig-like C2-type. DOMAIN 2799 3053 Protein kinase. NP_BIND 2805 2813 ATP (By similarity). ACT_SITE 2918 2918 Proton acceptor (By similarity). BINDING 2828 2828 ATP (By similarity). MOD_RES 2282 2282 Phosphoserine (By similarity). MOD_RES 2458 2458 Phosphoserine. MOD_RES 2462 2462 Phosphoserine (By similarity). DISULFID 2709 2762 By similarity. |
Keyword | Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Disulfide bond; Guanine-nucleotide releasing factor; Immunoglobulin domain; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; SH3 domain; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 3102 AA |
Protein Sequence | MSGSSGGATA PAASSGPAAA ASAAGSGCGG GAGEGAEEAA KDLADIAAFF RSGFRKNDEM 60 KAMDVLPILK EKVAYLSGGR DKRGGPILTF PARSNHDRIR QEDLRRLISY LACIPSEEVC 120 KRGFTVIVDM RGSKWDSIKP LLKILQESFP CCIHIALIIK PDNFWQKQRT NFGSSKFEFE 180 TNMVSLEGLT KVVDPSQLTP EFDGCLEYNH EEWIEIRVAF EEYISNAAHM LSRLEELQDV 240 LAKKELPQDL EGARNMIDEH SQLKKKVIKA PIEDLDLEGQ KLLQRIQSSD SFPKKNSGSG 300 NADLQNLLPK VSTMLDRLHS TRQHLHQMWH VRKLKLDQCF QLRLFEQDAE KMFDWITHNK 360 GLFLNSYTEI GTSHPHAMEL QTQHNHFAMN CMNVYVNINR IMSVANRLVE SGHYASQQIK 420 QIANQLEQEW KAFAAALDER STLLDMSSIF HQKAEKYMSN VDSWCKACGE VDLPSELQDL 480 EDAIHHHQGI YEHITLAYSE VSQDGKSLLD KLQRPLTPGS SDSLTASANY SKAVHHVLDV 540 IHEVLHHQRQ LENIWQHRKV RLHQRLQLCV FQQDVQQVLD WIENHGEAFL SKHTGVGKSL 600 HRARALQKRH EDFEEVAQNT YTNADKLLEA AEQLAQTGEC DPEEIYQAAH QLEDRIQDFV 660 RRVEQRKILL DMSVSFHTHV KELWTWLEEL QKELLDDVYA ESVEAVQDLI KRFGQQQQTT 720 LQVTVNVIKE GEDLIQQLRD SAISSNKTPH NSSINHIETV LQQLDEAQSQ MEELFQERKI 780 KLELFLQLRI FERDAIDIIS DLESWNDELS QQMNDFDTED LTIAEQRLQH HADKALTMNN 840 LTFDVIHQGQ DLLQYVNEVQ ASGVELLCDR DVDMATRVQD LLEFLHEKQQ ELDLAAEQHR 900 KHLEQCVQLR HLQAEVKQVL GWIRNGESML NAGLITASSL QEAEQLQREH EQFQHAIEKT 960 HQSALQVQQK AEAMLQANHY DMDMIRDCAE KVASHWQQLM LKMEDRLKLV NASVAFYKTS 1020 EQVCSVLESL EQEYKREEDW CGGADKLGPN SETDHVTPMI SKHLEQKEAF LKACTLARRN 1080 ADVFLKYLHR NSVSMPGMVT HIKAPEQQVK NILNELFQRE NRVLHYWTMR KRRLDQCQQY 1140 VVFERSAKQA LEWIHDNGEF YLSTHTSTGS SIQHTQELLK EHEEFQITAK QTKERVKLLI 1200 QLADGFCEKG HAHAAEIKKC VTAVDKRYRD FSLRMEKYRT SLEKALGISS DSNKSSKSLQ 1260 LDIIPASIPG SEVKLRDAAH ELNEEKRKSA RRKEFIMAEL IQTEKAYVRD LRECMDTYLW 1320 EMTSGVEEIP PGIVNKELII FGNMQEIYEF HNNIFLKELE KYEQLPEDVG HCFVTWADKF 1380 QMYVTYCKNK PDSTQLILEH AGSYFDEIQQ RHGLANSISS YLIKPVQRIT KYQLLLKELL 1440 TCCEEGKGEI KDGLEVMLSV PKRANDAMHL SMLEGFDENI ESQGELILQE SFQVWDPKTL 1500 IRKGRERHLF LFEMSLVFSK EVKDSSGRSK YLYKSKLFTS ELGVTEHVEG DPCKFALWVG 1560 RTPTSDNKIV LKASSIENKQ DWIKHIREVI QERTVHLRGA LKEPIHIPKT APAARQKGRR 1620 DGEDLDSQGD GSSQPDTISI ASRTSQNTLD SDKLSGGCEL TVVIHDFTAC NSNELTIRRG 1680 QTVEVLERPH DKPDWCLVRT TDRSPAAEGL VPCGSLCIAH SRSSMEMEGI FNHKDSLSVS 1740 SNDASPPASV ASLQPHMIGA QSSPGPKRPG NTLRKWLTSP VRRLSSGKAD GHAKKLAHKH 1800 KKSREVRKSA DAGSQKDSDD SAATPQDETI EERGRNEGLS SGTLSKSSSS GMQSCGEEEG 1860 EEGADAVPLP PPMAIQQHSL LQPDSQDDKA SSRLLVRPTS SETPSAAELV SAIEELVKSK 1920 MALEDRPSSL LVDQGDSSSP SFNPSDNSLL SSSSPIDEME ERKCSSLKRR HYVLQELVET 1980 ERDYVRDLGC VVEGYMALMK EDGVPDDMKG KDKIVFGNIH QIYDWHRDFF LGELEKCLED 2040 PEKLGSLFVK HERRLHMYIV YCQNKPKSEH IVSEYIDTFF EDLKQRLGHR LQLTDLLIKP 2100 VQRIMKYQLL LKDFLKYSKK ASLDTSELEK AVEVMCIVPK RCNDMMNVGR LQGFDGKIVA 2160 QGKLLLQDTF LVTDQDAGLL PRCKERRVFL FEQIVIFSEP LDKKKGFSMP GFLFKNSIKV 2220 SCLCLEENVE SDPCKFALTS RTGDAVETFV LHSSSPSVRQ TWIHEINQIL ENQRNFLNAL 2280 TSPIEYQRNH SGGGGSGSGG SSGGGGGSGG SGASSGGSSS HGSGPSSCSS GPSSSRSRPS 2340 RIPQPVRHHP PMLVSSAASS QAEADKMSGM SAPSPSLPTP SSSLALEASL GQPSRLPLSG 2400 DSEGHERETE PIPKMKVMES PRKAPGSTSG TSQDGNTKDA RGNLGSLPLG KTRPGAVSPL 2460 NSPLSTTFPS PFGKEAFPPS SPLQKGGSFW SSIPASPASR PSSFTFPGDS DSLQRQTHRH 2520 AAPSKDTDRM STCSSASEQS VQSTQSNGEG SSSSNISTML VTHEYTAVKE DEINVYQGEV 2580 VQILASNQQN MFLVFRAATD QCPAAEGWIP GFVLGHTSAV IMENPDGTLK KSTSWHTALR 2640 LRKKSEKKDK DGKRDGKLEN GYRKPREGLS NKVSVKLLNP NYIYDVPPEF VIPLSEVTCE 2700 TGETVVFRCR VCGRPKASIT WKGPEHNTLN NDDHYSISYS DIGEATLKII GVSTEDDGIY 2760 TCIAVNDMGS ASSSASLRVL GPGSDGIVVT WKDNFDAFYS EVAELGRGRF AVVKKCDQKG 2820 TKRAVATKFV NKKLMKRDQV THELGILQNL QHPLLVSLLD TFETPTSYVL VLEMADQGRL 2880 LDCVVRWGSL TEGKVRAHLG EVLEAVRYLH NCRIAHLDLK PENILVDQSL AKPTIKLADF 2940 GDAVQLNTTY YIHQLLGNPE FAAPEIILGN PVSLTADTWS VGVLTYVLLS GVSPFLDDSV 3000 EETCLNICRL DFSFPEDYFQ GVSQKAKEFV CFLLQEDPAK RPSAALALQE QWLQAGNGSG 3060 KGTGVLDTSR LTSFIERRKH QNDVRPIRSI KNFLQSRLLP RV 3102 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |