Tag | Content |
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CPLM ID | CPLM-014182 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Small ubiquitin-related modifier 3 |
Protein Synonyms/Alias | SUMO-3 |
Gene Name | Sumo3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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5 | ***MSEEKPKEGVKT | acetylation | [1] | 7 | *MSEEKPKEGVKTEN | acetylation | [1] | 11 | EKPKEGVKTENDHIN | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (By similarity). |
Sequence Annotation | DOMAIN 15 92 Ubiquitin-like. CROSSLNK 11 11 Glycyl lysine isopeptide (Lys-Gly) CROSSLNK 92 92 Glycyl lysine isopeptide (Gly-Lys) |
Keyword | Complete proteome; Cytoplasm; Isopeptide bond; Reference proteome; Ubl conjugation; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 110 AA |
Protein Sequence | MSEEKPKEGV KTENDHINLK VAGQDGSVVQ FKIKRHTPLS KLMKAYCERQ GLSMRQIRFR 60 FDGQPINETD TPAQLEMEDE DTIDVFQQQT GGTASRASVP TPSHFPDICY 110 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0016604; C:nuclear body; IEA:Compara. GO:0019789; F:SUMO ligase activity; IEA:Compara. GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Compara. GO:0034504; P:protein localization to nucleus; IEA:Compara. GO:0016925; P:protein sumoylation; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |