| Tag | Content |
|---|
| CPLM ID | CPLM-013114 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | RNA polymerase II elongation factor ELL2 |
Protein Synonyms/Alias | |
Gene Name | Ell2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 583 | KRLSPGSKEYQNVHE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (By similarity). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. |
Sequence Annotation | MOD_RES 501 501 Phosphoserine (By similarity).
MOD_RES 579 579 Phosphoserine (By similarity). |
Keyword | Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 639 AA |
Protein Sequence | MAAGGAAGLR EEQRYGLACG RLGQDNITVL HVKLTETAIR ALETYQSHKN LIPFRPSIQF 60
QGLQGLMKIP KNDPFNEVQN FNFYLSNVGR DNPQGSFDCI QQTLSSSGAS QLNCLGFIQD 120
KITVCATNDS YQMTRERMTQ AEEESRNRST KVIKPGGPYV GKRVQIRKAP QAISDTVPER 180
KRSTPMNPAN TIRKMHSGNS VSQRPYRDRV IHLLALKAYK KPELLARLQK DGVNQKDKNS 240
LGAILQQVAN LNPKDLSYTL KDYVFKELQR DWPGYSETDR QTLDLVLSRK LNPSQNASTS 300
RSESPLCSSK DAASSPQKRP LDSDFIDPLM NKKARISHLT NRVPPTLNGY LNPTSEKSCA 360
GLLPPPAAAA IPTLSPLPST HLPVSNPPQT VNSNSNSPST PEGLGTQDLP VDSFSQNGSI 420
FEDQQEKYTS RTCLETLPPS SALLKCPKPM EEEHPVSHKK SKKKSKKHKE KDQIKKLDIE 480
TMEEKEEDLQ REETAKLSNA SPNPNEGVKE GCTASMEPSS ALELPDYLIK YIAIVSYEQR 540
QNYKDDFNAE YDEYRALHAR METVARRFIK LDAQRKRLSP GSKEYQNVHE EVLQEYQKIK 600
QSSPNYHEEK YRCEYLHNKL AHIKRLIGEF DQQQAESWH 639 |
Gene Ontology | GO:0008023; C:transcription elongation factor complex; IEA:InterPro. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |