CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019409
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Exocyst complex component 2 
Protein Synonyms/Alias
 Exocyst complex component Sec5 
Gene Name
 EXOC2 
Gene Synonyms/Alias
 SEC5; SEC5L1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
68VCRVGQAKNDKGDIIubiquitination[1]
71VGQAKNDKGDIIVTTubiquitination[1]
79GDIIVTTKSGGRGTSubiquitination[1]
122DMRTDRNKGIPPLSLubiquitination[1]
143GIEIEKSKFSQKDLEubiquitination[1]
191KMAVTNLKRQANKKSubiquitination[1]
206EGSLAYVKGGLSTFFubiquitination[1]
225ALSAIHQKLEADGTEubiquitination[2]
233LEADGTEKVEGSMTQubiquitination[2]
241VEGSMTQKLENVLNRubiquitination[1, 2]
281LNVLQRFKFLFNLPLubiquitination[1]
296NIERNIQKGDYDVVIubiquitination[1, 2, 3, 4, 5]
308VVINDYEKAKSLFGKubiquitination[2]
310INDYEKAKSLFGKTEubiquitination[1]
315KAKSLFGKTEVQVFKubiquitination[1]
323TEVQVFKKYYAEVETubiquitination[1]
342LRELLLDKLLETPSTubiquitination[1]
354PSTLHDQKRYIRYLSubiquitination[1]
394SCKEGYVKDLKGNPGubiquitination[1]
428LSQTASLKRGSSFQSubiquitination[1]
454HRVAFVEKLTKLVLSacetylation[6]
515EVMHSLVKLTRGALLubiquitination[1]
532SIRDGEAKQYGGWEVubiquitination[1, 2]
639LKGVLECKPGEASVFubiquitination[1]
753QVSMASLKELDQRLFubiquitination[1, 2]
848QCVSSFSKNGALQARubiquitination[1]
878PESKSSFKQALEALPubiquitination[1]
902LLEELLNKFKSSMHLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [6] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. 
Sequence Annotation
 DOMAIN 8 93 IPT/TIG.
 MOD_RES 435 435 Phosphoserine (By similarity).
 MOD_RES 454 454 N6-acetyllysine.  
Keyword
 Acetylation; Coiled coil; Complete proteome; Exocytosis; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 924 AA 
Protein Sequence
MSRSRQPPLV TGISPNEGIP WTKVTIRGEN LGTGPTDLIG LTICGHNCLL TAEWMSASKI 60
VCRVGQAKND KGDIIVTTKS GGRGTSTVSF KLLKPEKIGI LDQSAVWVDE MNYYDMRTDR 120
NKGIPPLSLR PANPLGIEIE KSKFSQKDLE MLFHGMSADF TSENFSAAWY LIENHSNTSF 180
EQLKMAVTNL KRQANKKSEG SLAYVKGGLS TFFEAQDALS AIHQKLEADG TEKVEGSMTQ 240
KLENVLNRAS NTADTLFQEV LGRKDKADST RNALNVLQRF KFLFNLPLNI ERNIQKGDYD 300
VVINDYEKAK SLFGKTEVQV FKKYYAEVET RIEALRELLL DKLLETPSTL HDQKRYIRYL 360
SDLHASGDPA WQCIGAQHKW ILQLMHSCKE GYVKDLKGNP GLHSPMLDLD NDTRPSVLGH 420
LSQTASLKRG SSFQSGRDDT WRYKTPHRVA FVEKLTKLVL SQLPNFWKLW ISYVNGSLFS 480
ETAEKSGQIE RSKNVRQRQN DFKKMIQEVM HSLVKLTRGA LLPLSIRDGE AKQYGGWEVK 540
CELSGQWLAH AIQTVRLTHE SLTALEIPND LLQTIQDLIL DLRVRCVMAT LQHTAEEIKR 600
LAEKEDWIVD NEGLTSLPCQ FEQCIVCSLQ SLKGVLECKP GEASVFQQPK TQEEVCQLSI 660
NIMQVFIYCL EQLSTKPDAD IDTTHLSVDV SSPDLFGSIH EDFSLTSEQR LLIVLSNCCY 720
LERHTFLNIA EHFEKHNFQG IEKITQVSMA SLKELDQRLF ENYIELKADP IVGSLEPGIY 780
AGYFDWKDCL PPTGVRNYLK EALVNIIAVH AEVFTISKEL VPRVLSKVIE AVSEELSRLM 840
QCVSSFSKNG ALQARLEICA LRDTVAVYLT PESKSSFKQA LEALPQLSSG ADKKLLEELL 900
NKFKSSMHLQ LTCFQAASST MMKT 924 
Gene Ontology
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set.
 IPR002909; IPT_TIG_rcpt. 
Pfam
 PF01833; TIG 
SMART
  
PROSITE
  
PRINTS