| Tag | Content |
|---|
| CPLM ID | CPLM-000605 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nuclear receptor subfamily 1 group I member 3 |
Protein Synonyms/Alias | Constitutive androstane receptor; CAR; Orphan nuclear receptor MB67 |
Gene Name | Nr1i3 |
Gene Synonyms/Alias | Car |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 51 | FFRRTVSKTIGPICP | ubiquitination | [1] | | 111 | QAQRRAEKASLQLNQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity). |
Sequence Annotation | DNA_BIND 18 93 Nuclear receptor.
ZN_FING 21 41 NR C4-type.
ZN_FING 57 81 NR C4-type.
MOD_RES 48 48 Phosphothreonine; by PKC (By similarity). |
Keyword | 3D-structure; Activator; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 358 AA |
Protein Sequence | MTAMLTLETM ASEEEYGPRN CVVCGDRATG YHFHALTCEG CKGFFRRTVS KTIGPICPFA 60
GRCEVSKAQR RHCPACRLQK CLNVGMRKDM ILSAEALALR RARQAQRRAE KASLQLNQQQ 120
KELVQILLGA HTRHVGPMFD QFVQFKPPAY LFMHHRPFQP RGPVLPLLTH FADINTFMVQ 180
QIIKFTKDLP LFRSLTMEDQ ISLLKGAAVE ILHISLNTTF CLQTENFFCG PLCYKMEDAV 240
HAGFQYEFLE SILHFHKNLK GLHLQEPEYV LMAATALFSP DRPGVTQREE IDQLQEEMAL 300
ILNNHIMEQQ SRLQSRFLYA KLMGLLADLR SINNAYSYEL QRLEELSAMT PLLGEICS 358 |
Gene Ontology | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0005829; C:cytosol; IDA:MGI. GO:0005634; C:nucleus; IDA:UniProtKB. GO:0003677; F:DNA binding; IDA:MGI. GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. GO:0003707; F:steroid hormone receptor activity; IEA:InterPro. GO:0004887; F:thyroid hormone receptor activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |