UniProt Accession

 RAB25_HUMAN; P57735; Q5VYA2; Q8NG24; Q96GB1; Q9BT12 

Genbank Protein ID

 AF083124; AF274025; AL355388; CH471121; BC004416; BC009831; BC033322 

Genbank Nucleotide ID

 AAF98238.1; AAM69362.1; CAH72638.1; EAW53003.1; AAH04416.1; AAH09831.1; AAH33322.1 

Protein Name

 Ras-related protein Rab-25 

Protein Synonyms/Alias

 CATX-8 

Gene Name

 RAB25 

Gene Synonyms/Alias

 CATX8 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
25	IGESGVGKTNLLSRF	ubiquitination	[1]
206	QEPGPGEKRACCISL	ubiquitination	[1, 2]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Increases the rates of ovarian and breast cancers progression and aggressiveness by modulating cellular processes such as proliferation, survival and migration of epithelial tumor cells. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity). 

Sequence Annotation

 NP_BIND 19 27 GTP.
 NP_BIND 67 71 GTP (By similarity).
 NP_BIND 125 128 GTP.
 NP_BIND 155 157 GTP.
 MOTIF 41 49 Effector region (By similarity).
 MOD_RES 210 210 Cysteine methyl ester (Potential).
 LIPID 209 209 S-geranylgeranyl cysteine (By
 LIPID 210 210 S-geranylgeranyl cysteine (By  

Keyword

 3D-structure; Cell membrane; Cell projection; Complete proteome; Cytoplasmic vesicle; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 213 AA 

Protein Sequence

Gene Ontology

 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
 GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB.
 GO:0031143; C:pseudopodium; IDA:UniProtKB.
 GO:0031260; C:pseudopodium membrane; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0031268; P:pseudopodium organization; IDA:UniProtKB.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.