CPLM-004098

Genbank Nucleotide ID

Interferon-induced transmembrane protein 1

Protein Synonyms/Alias

Dispanin subfamily A member 2a; DSPA2a; Interferon-induced protein 17; Interferon-inducible protein 9-27; Leu-13 antigen; CD225

Homo sapiens (Human)

Position	Peptide	Type	References
3	*****MHKEEHEVAV	ubiquitination	[1, 2, 3]
67	SVKSRDRKMVGDVTG	ubiquitination	[2]

[1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
[2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]

Functional Description

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein- mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation.

REGION 84 125 Interaction with CAV1.
LIPID 50 50 S-palmitoyl cysteine (By similarity).
LIPID 51 51 S-palmitoyl cysteine (By similarity).
LIPID 84 84 S-palmitoyl cysteine (By similarity).

Antiviral defense; Cell membrane; Complete proteome; Immunity; Innate immunity; Lipoprotein; Membrane; Osteogenesis; Palmitate; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005057; F:receptor signaling protein activity; TAS:ProtInc.
GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO:0030336; P:negative regulation of cell migration; IMP:UniProtKB.
GO:0008285; P:negative regulation of cell proliferation; IMP:UniProtKB.
GO:0046597; P:negative regulation of viral entry into host cell; IDA:UniProtKB.
GO:0045071; P:negative regulation of viral genome replication; IDA:UniProtKB.
GO:0001503; P:ossification; IEA:UniProtKB-KW.
GO:0045669; P:positive regulation of osteoblast differentiation; IMP:UniProtKB.
GO:0050776; P:regulation of immune response; TAS:Reactome.
GO:0035455; P:response to interferon-alpha; IDA:UniProtKB.
GO:0035456; P:response to interferon-beta; IDA:UniProtKB.
GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.
GO:0009615; P:response to virus; IDA:UniProtKB.
GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome.

IPR007593; Interferon-induced_TM_protein.