CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033069
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Probable E3 ubiquitin-protein ligase makorin-2 
Protein Synonyms/Alias
  
Gene Name
 MKRN2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
42TICKYYQKGYCAYGTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 414 AA 
Protein Sequence
MSTKQITCRY FMHGVCREGS QCLFSHDLAN SKPSTICKYY QKGYCAYGTR YDHTRPSAAA 60
GGAVGTMAHS VPSPAFHSPH PPSEVTASIV KTNSHEPGKR EKRTLVLRDR NLSGMAERKT 120
QPSMVSNPGS CSDPQPSPEM KPHSYLDAIR SGLDDVEASS SYSNEQQLCP YAAAGECRFG 180
DACVYLHGEV CEICRLQVLH PFDPEQRKAH EKICMLTFEH EMEKAFAFQA SQDKVCSICM 240
EVILEKASAS ERRFGILSNC NHTYCLSCIR QWRCAKQFEN PIIKSCPECR VISEFVIPSV 300
YWVEDQNKKN ELIEAFKQGM GKKACKYFEQ GKGTCPFGSK CLYRHAYPDG RLAEPEKPRK 360
QLSSQGTVRF FNSVRLWDFI ENRESRHVPN NEDVDMTELG DLFMHLSGVE SSEP 414 
Gene Ontology
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR026290; Makorin-related.
 IPR026293; Makorin_2.
 IPR000571; Znf_CCCH.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF00642; zf-CCCH
 PF13639; zf-RING_2 
SMART
 SM00184; RING
 SM00356; ZnF_C3H1 
PROSITE
 PS50103; ZF_C3H1
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS