CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028254
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nejire, isoform B 
Protein Synonyms/Alias
 Nejire, isoform D 
Gene Name
 nej 
Gene Synonyms/Alias
 CG15321; Dmel_CG15319 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
1554NAGGMASKGKLDSIKacetylation[1]
1556GGMASKGKLDSIKQDacetylation[1]
1561KGKLDSIKQDDDIKKacetylation[1]
1567IKQDDDIKKEFMDDSacetylation[1]
1594STGGGKGKNVNNDGTacetylation[1]
1609SMIKMEIKTEDGLDGacetylation[1]
1619DGLDGEVKIKTEAMDacetylation[1]
1621LDGEVKIKTEAMDVDacetylation[1]
1652GSGVGGGKDNINGAHacetylation[1]
1677IKPKTETKPLVPEPLacetylation[1]
1828QVLCCYGKQLCTIPRacetylation[1]
1838CTIPRDAKYYSYQNSacetylation[1]
1847YSYQNSLKEYGVASNacetylation[1]
2212NEVSGDGKKKGQKKAacetylation[1]
2221KGQKKAKKSNKSKAAacetylation[1]
2224KKAKKSNKSKAAQRKacetylation[1]
2226AKKSNKSKAAQRKNSacetylation[1]
2231KSKAAQRKNSKKSNEacetylation[1]
2234AAQRKNSKKSNEHQSacetylation[1]
2235AQRKNSKKSNEHQSGacetylation[1]
2248SGNDLSTKIYATMEKacetylation[1]
2255KIYATMEKHKEVFFVacetylation[1]
2339VYTCNHCKTAVETRYacetylation[1]
2372GHQHKMEKLGFDIDDacetylation[1]
2387GSALADHKQANPQEAacetylation[1]
2476FCPNIKHKLKQQQSQacetylation[1]
2478PNIKHKLKQQQSQQKacetylation[1]
2485KQQQSQQKFQQQQLLacetylation[1]
2624SHGGGFGKGVPMAPPacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Acyltransferase; Bromodomain; Complete proteome; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3276 AA 
Protein Sequence
MMADHLDEPP QKRVKMDPTD ISYFLEENLP DELVSSNSGW SDQLTGGAGG GNGGGGASGV 60
TTNPTSGPNP GGGPNKPAAQ GPGSGTGGVG VGVNVGVGGV VGVGVVPSQM NGAGGGNGSG 120
TGGDDGSGNG SGAGNRISQM QHQQLQHLLQ QQQQGQKGAM VVPGMQQLGS KSPNLQSPNQ 180
GGMQQVVGTQ MGMVNSMPMS ISNNGNNGMN AIPGMNTIAQ GNLGNMVLTN SVGGGMGGMV 240
NHLKQQPGGG GGGMINSVSV PGGPGAGAGG VGAGGGGAVA ANQGMHMQNG PMMGRMVGQQ 300
HMLRGPHLMG ASGGAGGPGN GPGGGGPRMQ NPNMQMTQLN SLPYGVGQYG GPGGGNNPQQ 360
QQQQQQQQLL AQQMAQRGGV VPGMPQGNRP VGTVVPMSTL GGDGSGPAGQ LVSGNPQQQQ 420
MLAQQQTGAM GPRPPQPNQL LGHPGQQQQQ QQQPGTSQQQ QQQQGVGIGG AGVVANAGTV 480
AGVPAVAGGG AGGAVQSSGP GGANRDVPDD RKRQIQQQLM LLLHAHKCNR RENLNPNREV 540
CNVNYCKAMK SVLAHMGTCK QSKDCTMQHC ASSRQILLHY KTCQNSGCVI CYPFRQNHSV 600
FQNANVPPGG GPAGIGGAPP GGGGAGGGAA GAGGNLQQQQ QQQQQQQQNQ QPNLTGLVVD 660
GKQGQQVAPG GGQNTAIVLP QQQGAGGAPG APKTPADMVQ QLTQQQQQQQ QQVHQQQVQQ 720
QELRRFDGMS QQVVAGGMQQ QQQQGLPPVI RIQGAQPAVR VLGPGGPGGP SGPNVLPNDV 780
NSLHQQQQQM LQQQQQQGQN RRRGGLATMV EQQQQHQQQQ QQPNPAQLGG NIPAPLSVNV 840
GGFGNTNFGG AAAGGAVGAN DKQQLKVAQV HPQSHGVGAG GASAGAGASG GQVAAGSSVL 900
MPADTTGSGN AGNPNQNAGG VAGGAGGGNG GNTGPPGDNE KDWRESVTAD LRNHLVHKLV 960
QAIFPTSDPT TMQDKRMHNL VSYAEKVEKD MYEMAKSRSE YYHLLAEKIY KIQKELEEKR 1020
LKRKEQHQQM LMQQQGVANP VAGGAAGGAG SAAGVAGGVV LPQQQQQQQQ QQQQQGQQPL 1080
QSCIHPSISP MGGVMPPQQL RPQGPPGILG QQTAAGLGVG VGVTNNMVTM RSHSPGGNML 1140
ALQQQQRMQF PQQQQQQPPG SGAGKMLVGP PGPSPGGMVV NPALSPYQTT NVLTSPVPGQ 1200
QQQQQFINAN GGTGANPQLS EIMKQRHIHQ QQQQQQQQQQ QGMLLPQSPF SNSTPLQQQQ 1260
QQQQQQQQQQ QATSNSFSSP MQQQQQGQQQ QQQKPGSVLN NMPPTPTSLE ALNAGAGAPG 1320
TGGSASNVTV SAPSPSPGFL SNGPSIGTPS NNNNNSSANN NPPSVSSLMQ QPLSNRPGTP 1380
PYIPASPVPA TSASGLAASS TPASAAATCA SSGSGSNSSS GATAAGASST SSSSSAGSGT 1440
PLSSVSTPTS ATMATSSGGG GGGGGNAGGG SSTTPASNPL LLMSGGTAGG GTGATTTTST 1500
SSSSRMMSSS SSLSSQMAAL EAAARDNDDE TPSPSGENTN GSGGSGNAGG MASKGKLDSI 1560
KQDDDIKKEF MDDSCGGNND SSQMDCSTGG GKGKNVNNDG TSMIKMEIKT EDGLDGEVKI 1620
KTEAMDVDEA GGSTAGEHHG EGGGGSGVGG GKDNINGAHD GGATGGAVDI KPKTETKPLV 1680
PEPLAPNAGD KKKKCQFNPE ELRTALLPTL EKLYRQEPES VPFRYPVDPQ ALGIPDYFEI 1740
VKKPMDLGTI RTNIQNGKYS DPWEYVDDVW LMFDNAWLYN RKTSRVYRYC TKLSEVFEAE 1800
IDPVMQALGY CCGRKYTFNP QVLCCYGKQL CTIPRDAKYY SYQNSLKEYG VASNRYTYCQ 1860
KCFNDIQGDT VTLGDDPLQS QTQIKKDQFK EMKNDHLELE PFVNCQECGR KQHQICVLWL 1920
DSIWPGGFVC DNCLKKKNSK RKENKFNAKR LPTTKLGVYI ETRVNNFLKK KEAGAGEVHI 1980
RVVSSSDKCV EVKPGMRRRF VEQGEMMNEF PYRAKALFAF EEVDGIDVCF FGMHVQEYGS 2040
ECPAPNTRRV YIAYLDSVHF FRPRQYRTAV YHEILLGYMD YVKQLGYTMA HIWACPPSEG 2100
DDYIFHCHPT DQKIPKPKRL QEWYKKMLDK GMIERIIQDY KDILKQAMED KLGSAAELPY 2160
FEGDFWPNVL EESIKELDQE EEEKRKQAEA AEAAAAANLF SIEENEVSGD GKKKGQKKAK 2220
KSNKSKAAQR KNSKKSNEHQ SGNDLSTKIY ATMEKHKEVF FVIRLHSAQS AASLAPIQDP 2280
DPLLTCDLMD GRDAFLTLAR DKHFEFSSLR RAQFSTLSML YELHNQGQDK FVYTCNHCKT 2340
AVETRYHCTV CDDFDLCIVC KEKVGHQHKM EKLGFDIDDG SALADHKQAN PQEARKQSIQ 2400
RCIQSLAHAC QCRDANCRLP SCQKMKLVVQ HTKNCKRKPN GGCPICKQLI ALCCYHAKNC 2460
EEQKCPVPFC PNIKHKLKQQ QSQQKFQQQQ LLRRRVALMS RTAAPAALQG PAAVSGPTVV 2520
SGGVPVVGMS GVAVSQQVIP GQAGILPPGA GGMSPSTVAV PSPVSGGAGA GGMGGMTSPH 2580
PHQPGIGMKP GGGHSPSPNV LQVVKQVQEE AARQQVSHGG GFGKGVPMAP PVMNRPMGGA 2640
GPNQNVVNQL GGMGVGVGGV GGVGVGGVGG VGVNQLNSGG GNTPGAPISG PGMNVNHLMS 2700
MDQWGGGGAG GGGANPGGGN PQARYANNTG GMRQPTHVMQ TNLIPPQQQQ QMMGGLGGPN 2760
QLGGGQMPVG GQHGGMGMGM GAPPMAGTVG GVRPSPGAGG GGGSATGGGL NTQQLALIMQ 2820
KIKNNPTNES NQHILAILKQ NPQIMAAIIK QRQQSQNNAA AGGGAPGPGG ALQQQQAGNG 2880
PQNPQQQQQQ QQQQQVMQQQ QMQHMMNQQQ GGGGPQQMNP NQQQQQQQVN LMQQQQQGGP 2940
GGPGSGLPTR MPNMPNALGM LQSLPPNMSP GVSTQGGMVP NQNWNKMRYM QMSQYPPPYP 3000
QRQRGPHMGG AGPGPGQQQF PGGGGGAGNF NAGGAGGAGG VVGVGGVPGG AGTVPGGDQY 3060
SMANAAAASN MLQQQQGQVG VGVGVGVKPG PGQQQQQMGV GMPPGMQQQQ QQQQPLQQQQ 3120
MMQVAMPNAN AQNPSAVVGG PNAQVMGPPT PHSLQQQLMQ SARSSPPIRS PQPTPSPRSA 3180
PSPRAAPSAS PRAQPSPHHV MSSHSPAPQG PPHDGMHNHG MHHQSPLPGV PQDVGVGVGV 3240
GVGVGVNVNV GNVGVGNAGG ALPDASDQLT KFVERL 3276 
Gene Ontology
 GO:0005634; C:nucleus; IDA:FlyBase.
 GO:0043234; C:protein complex; IPI:FlyBase.
 GO:0008140; F:cAMP response element binding protein binding; TAS:FlyBase.
 GO:0043993; F:histone acetyltransferase activity (H3-K18 specific); IDA:FlyBase.
 GO:0044017; F:histone acetyltransferase activity (H3-K27 specific); IDA:FlyBase.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0032922; P:circadian regulation of gene expression; IMP:FlyBase.
 GO:0000076; P:DNA replication checkpoint; IMP:FlyBase.
 GO:0008347; P:glial cell migration; IMP:FlyBase.
 GO:0030097; P:hemopoiesis; TAS:FlyBase.
 GO:0043983; P:histone H4-K12 acetylation; IMP:FlyBase.
 GO:0043982; P:histone H4-K8 acetylation; IMP:FlyBase.
 GO:0045475; P:locomotor rhythm; IMP:FlyBase.
 GO:0007269; P:neurotransmitter secretion; IMP:FlyBase.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:FlyBase.
 GO:0007464; P:R3/R4 cell fate commitment; IMP:FlyBase.
 GO:0045466; P:R7 cell differentiation; IMP:FlyBase.
 GO:0007088; P:regulation of mitosis; IMP:FlyBase.
 GO:0007224; P:smoothened signaling pathway; IMP:FlyBase.
 GO:0007416; P:synapse assembly; IMP:FlyBase.
 GO:0016055; P:Wnt receptor signaling pathway; NAS:FlyBase. 
Interpro
 IPR001487; Bromodomain.
 IPR018359; Bromodomain_CS.
 IPR010303; DUF902_CREBbp.
 IPR013178; Histone_H3-K56_AcTrfase_RTT109.
 IPR003101; KIX_dom.
 IPR009110; Nuc_rcpt_coact.
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR000197; Znf_TAZ.
 IPR000433; Znf_ZZ. 
Pfam
 PF00439; Bromodomain
 PF06001; DUF902
 PF08214; KAT11
 PF02172; KIX
 PF02135; zf-TAZ
 PF00569; ZZ 
SMART
 SM00297; BROMO
 SM00551; ZnF_TAZ
 SM00291; ZnF_ZZ 
PROSITE
 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2
 PS50952; KIX
 PS01359; ZF_PHD_1
 PS50134; ZF_TAZ
 PS01357; ZF_ZZ_1
 PS50135; ZF_ZZ_2 
PRINTS
 PR00503; BROMODOMAIN.