CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016053
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Inositol hexakisphosphate kinase 2 
Protein Synonyms/Alias
 InsP6 kinase 2; P(i)-uptake stimulator; PiUS 
Gene Name
 Ip6k2 
Gene Synonyms/Alias
 Ihpk2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
244VPCVLDLKMGTRQHGubiquitination[1]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Was first identified because of its ability to stimulate Na(+)-dependent phosphate cotransport (By similarity). 
Sequence Annotation
 REGION 238 246 Substrate binding (By similarity).  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 448 AA 
Protein Sequence
MSPAFRTMDV EPRTKGILLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ FYETLPAEMR 60
RFTPQYKAVL IFVRCADEFG ASGNIETKEQ GVVSVRFEED EDRNLCLIAY PLKGDHGTVD 120
IVDNSDCEPK SKLLRWTNKK HHALETEKNP KDWVRQHRKE EKMKSHKLEE EFEWLKKSEV 180
LYYSVEKKGN VSSQLKHYNP WSMKCHQQQL QRMKENAKHR NQYKFILLEN LTSRYEVPCV 240
LDLKMGTRQH GDDASEEKAA NQIRKCQQST SAVIGVRVCG MQVYQAGTGQ LMFMNKYHGR 300
KLSVQGFKEA LFQFFHNGRY LRRELLGPVL KKLTELKAVL ERQESYRFYS SSLLVIYDGK 360
EWPEVTLDSD AEDLEDLSEE SADESAGAYA YKPIGASSVD VRMIDFAHTT CRLYGEDSVV 420
HEGQDAGYIF GLQSLIDIVT EISEESGE 448 
Gene Ontology
 GO:0045111; C:intermediate filament cytoskeleton; IEA:Compara.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0052723; F:inositol hexakisphosphate 1-kinase activity; IEA:EC.
 GO:0052724; F:inositol hexakisphosphate 3-kinase activity; IEA:EC.
 GO:0000832; F:inositol hexakisphosphate 5-kinase activity; IEA:EC.
 GO:0008440; F:inositol-1,4,5-trisphosphate 3-kinase activity; IEA:InterPro.
 GO:0030308; P:negative regulation of cell growth; IEA:Compara.
 GO:0006817; P:phosphate ion transport; IEA:Compara.
 GO:0046854; P:phosphatidylinositol phosphorylation; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara. 
Interpro
 IPR005522; IPK. 
Pfam
 PF03770; IPK 
SMART
  
PROSITE
  
PRINTS