UniProt Accession

 PAX6_MOUSE; P63015; P32117; P70601; Q62222; Q64037; Q8CEI5; Q8VDB5; Q921Q8 

Genbank Protein ID

 X63963; X63963; Y19196; Y19199; AK028059; BC011272; BC036957; M77842 

Genbank Nucleotide ID

 CAA45379.1; CAA45380.1; CAC80516.1; CAC80519.1; BAC25729.1; AAH11272.1; AAH36957.1; AAA40109.1 

Protein Name

 Paired box protein Pax-6 

Protein Synonyms/Alias

 Oculorhombin 

Gene Name

 Pax6 

Gene Synonyms/Alias

 Pax-6; Sey 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
91	VSKIAQYKRECPSIF	sumoylation	[1]

Reference

 [1] Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development.
 Yan Q, Gong L, Deng M, Zhang L, Sun S, Liu J, Ma H, Yuan D, Chen PC, Hu X, Liu J, Qin J, Xiao L, Huang XQ, Zhang J, Li DW.
 Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21034-9. [PMID: 21084637] 

Functional Description

 Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). 

Sequence Annotation

 DOMAIN 4 130 Paired.
 DNA_BIND 210 269 Homeobox.  

Keyword

 Alternative splicing; Complete proteome; Developmental protein; Differentiation; Direct protein sequencing; Disease mutation; DNA-binding; Homeobox; Nucleus; Paired box; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 422 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
 GO:0005667; C:transcription factor complex; TAS:MGI.
 GO:0003680; F:AT DNA binding; IEA:Compara.
 GO:0070410; F:co-SMAD binding; IDA:BHF-UCL.
 GO:0003690; F:double-stranded DNA binding; IEA:Compara.
 GO:0035035; F:histone acetyltransferase binding; IDA:BHF-UCL.
 GO:0070412; F:R-SMAD binding; IDA:BHF-UCL.
 GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IDA:BHF-UCL.
 GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IDA:BHF-UCL.
 GO:0048708; P:astrocyte differentiation; IMP:MGI.
 GO:0007411; P:axon guidance; IMP:MGI.
 GO:0001568; P:blood vessel development; IEA:Compara.
 GO:0001709; P:cell fate determination; IMP:MGI.
 GO:0021796; P:cerebral cortex regionalization; IMP:MGI.
 GO:0021902; P:commitment of neuronal cell to specific neuron type in forebrain; IMP:MGI.
 GO:0061303; P:cornea development in camera-type eye; IEA:Compara.
 GO:0009950; P:dorsal/ventral axis specification; IMP:MGI.
 GO:0048596; P:embryonic camera-type eye morphogenesis; IGI:MGI.
 GO:0042462; P:eye photoreceptor cell development; IMP:MGI.
 GO:0021797; P:forebrain anterior/posterior pattern specification; IMP:MGI.
 GO:0021798; P:forebrain dorsal/ventral pattern formation; IMP:MGI.
 GO:0021905; P:forebrain-midbrain boundary formation; IMP:MGI.
 GO:0042593; P:glucose homeostasis; IEA:Compara.
 GO:0030902; P:hindbrain development; IEA:Compara.
 GO:0061072; P:iris morphogenesis; IEA:Compara.
 GO:0030216; P:keratinocyte differentiation; IMP:MGI.
 GO:0032808; P:lacrimal gland development; IMP:MGI.
 GO:0002088; P:lens development in camera-type eye; IMP:MGI.
 GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:MGI.
 GO:0045665; P:negative regulation of neuron differentiation; IGI:MGI.
 GO:0001764; P:neuron migration; IMP:MGI.
 GO:0021778; P:oligodendrocyte cell fate specification; IMP:MGI.
 GO:0003322; P:pancreatic A cell development; IMP:BHF-UCL.
 GO:0021983; P:pituitary gland development; IMP:MGI.
 GO:0042660; P:positive regulation of cell fate specification; IEA:Compara.
 GO:0030858; P:positive regulation of epithelial cell differentiation; IMP:MGI.
 GO:0002052; P:positive regulation of neuroblast proliferation; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0033365; P:protein localization to organelle; IMP:MGI.
 GO:0030334; P:regulation of cell migration; IMP:MGI.
 GO:0048505; P:regulation of timing of cell differentiation; IMP:MGI.
 GO:0021918; P:regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment; IMP:MGI.
 GO:0021912; P:regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification; IMP:MGI.
 GO:0021913; P:regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification; IMP:MGI.
 GO:0009611; P:response to wounding; IEA:Compara.
 GO:0007435; P:salivary gland morphogenesis; IMP:MGI.
 GO:0023019; P:signal transduction involved in regulation of gene expression; IDA:MGI.
 GO:0007224; P:smoothened signaling pathway; IDA:MGI.
 GO:0003309; P:type B pancreatic cell differentiation; IMP:MGI. 

Interpro

 IPR017970; Homeobox_CS.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like.
 IPR001523; Paired_dom.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00046; Homeobox
 PF00292; PAX 

SMART

 SM00389; HOX
 SM00351; PAX 

PROSITE

 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2
 PS00034; PAIRED_1
 PS51057; PAIRED_2 

PRINTS

 PR00027; PAIREDBOX.