CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011396
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rho-type GTPase-activating protein 2 
Protein Synonyms/Alias
  
Gene Name
 RGA2 
Gene Synonyms/Alias
 YDR379W; D9481.4 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
700PSSNSDRKGSISNASubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 GTPase-activating protein (GAP) for CDC42 and/or RHO1. 
Sequence Annotation
 DOMAIN 11 68 LIM zinc-binding 1.
 DOMAIN 69 129 LIM zinc-binding 2.
 DOMAIN 788 1006 Rho-GAP.
 MOD_RES 763 763 Phosphoserine.  
Keyword
 Complete proteome; GTPase activation; LIM domain; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1009 AA 
Protein Sequence
MSADPINDQS SLCVRCNKSI ASSQVYELES KKWHDQCFTC YKCDKKLNAD SDFLVLDIGT 60
LICYDCSDKC TNCGDKIDDT AIILPSSNEA YCSNCFRCCR CSNRIKNLKY AKTKRGLCCM 120
DCHEKLLRKK QLLLENQTKN SSKEDFPIKL PERSVKRPLS PTRINGKSDV STNNTAISKN 180
LVSSNEDQQL TPQVLVSQER DESSLNDNND NDNSKDREET SSHARTVSID DILNSTLEHD 240
SNSIEEQSLV DNEDYINKMG EDVTYRLLKP QRANRDSIVV KDPRIPNSNS NANRFFSIYD 300
KEETDKDDTD NKENEIIVNT PRNSTDKITS PLNSPMAVQM NEEVEPPHGL ALTLSEATKE 360
NNKSSQGIQT STSKSMNHVS PITRTDTVEM KTSTSSSTLR LSDNGSFSRP QTADNLLPHK 420
KVAPSPNKKL SRSFSLKSKN FVHNLKSKTS EMLDPKHPHH STSIQESDTH SGWGVSSTHT 480
NIRKSKAKKN PVSRGQSDST IYNTLPQHGN FTVPEFNHKK AQSSLGSISK KQNSNDTATN 540
RRINGSFTSS SSGHHIAMFR TPPLESGPLF KRPSLSSESA HHRSSSLQTS RSTNALLEDD 600
STKVDATDES ATSLEKDFYF TELTLRKLKL DVRELEGTKK KLLQDVENLR LAKERLLNDV 660
DNLTREKDKQ SASSRESLEQ KENIATSITV KSPSSNSDRK GSISNASPKP RFWKIFSSAK 720
DHQVGDLESQ QRSPNSSSGG TTNIAQKEIS SPKLIRVHDE LPSPGKVPLS PSPKRLDYTP 780
DGSHLYGSSL QARCAYEKST VPIIIRCCID RIEKDDIGLN MEGLYRKSGS QTLVEEIENE 840
FAQNNSLHSD TLSPKLNALL NQDIHAVASV LKRYLRKLPD PVLSFSIYDA LIDLVRNNQL 900
IERLPLNNDK FLDSPQKVTI YEMVLKSLLE IFKILPVEHQ EVLKVLAAHI GKVRRCSERN 960
LMNLHNLSLV FAPSLIHDFD GEKDIVDMKE RNYIVEFILG NYRDIFKQA 1009 
Gene Ontology
 GO:0032177; C:cellular bud neck split septin rings; IDA:SGD.
 GO:0005100; F:Rho GTPase activator activity; IDA:SGD.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007015; P:actin filament organization; ISS:SGD.
 GO:0007118; P:budding cell apical bud growth; ISS:SGD.
 GO:0007119; P:budding cell isotropic bud growth; ISS:SGD.
 GO:0030010; P:establishment of cell polarity; TAS:SGD.
 GO:0001403; P:invasive growth in response to glucose limitation; ISS:SGD.
 GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; TAS:SGD.
 GO:0007124; P:pseudohyphal growth; ISS:SGD.
 GO:0007264; P:small GTPase mediated signal transduction; TAS:SGD. 
Interpro
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom.
 IPR001781; Znf_LIM. 
Pfam
 PF00412; LIM
 PF00620; RhoGAP 
SMART
 SM00132; LIM
 SM00324; RhoGAP 
PROSITE
 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2
 PS50238; RHOGAP 
PRINTS