CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004029
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bone morphogenetic protein 4 
Protein Synonyms/Alias
 BMP-4; Bone morphogenetic protein 2B; BMP-2B 
Gene Name
 BMP4 
Gene Synonyms/Alias
 BMP2B; DVR4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
185INIYEVMKPPAEVVPubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). 
Sequence Annotation
 CARBOHYD 143 143 N-linked (GlcNAc...) (Potential).
 CARBOHYD 208 208 N-linked (GlcNAc...) (Potential).
 CARBOHYD 350 350 N-linked (GlcNAc...) (Potential).
 CARBOHYD 365 365 N-linked (GlcNAc...) (Potential).
 DISULFID 308 373 By similarity.
 DISULFID 337 405 By similarity.
 DISULFID 341 407 By similarity.
 DISULFID 372 372 Interchain (By similarity).  
Keyword
 Chondrogenesis; Cleavage on pair of basic residues; Complete proteome; Cytokine; Developmental protein; Differentiation; Disease mutation; Disulfide bond; Extracellular matrix; Glycoprotein; Growth factor; Microphthalmia; Osteogenesis; Polymorphism; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 408 AA 
Protein Sequence
MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT 60
LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEQIH STGLEYPERP ASRANTVRSF 120
HHEEHLENIP GTSENSAFRF LFNLSSIPEN EVISSAELRL FREQVDQGPD WERGFHRINI 180
YEVMKPPAEV VPGHLITRLL DTRLVHHNVT RWETFDVSPA VLRWTREKQP NYGLAIEVTH 240
LHQTRTHQGQ HVRISRSLPQ GSGNWAQLRP LLVTFGHDGR GHALTRRRRA KRSPKHHSQR 300
ARKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL 360
VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR 408 
Gene Ontology
 GO:0005615; C:extracellular space; ISS:UniProtKB.
 GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
 GO:0070700; F:BMP receptor binding; IDA:MGI.
 GO:0042056; F:chemoattractant activity; IDA:UniProtKB.
 GO:0005125; F:cytokine activity; IDA:MGI.
 GO:0008201; F:heparin binding; IEA:Compara.
 GO:0000186; P:activation of MAPKK activity; IDA:UniProtKB.
 GO:0009948; P:anterior/posterior axis specification; IEA:Compara.
 GO:0002043; P:blood vessel endothelial cell proliferation involved in sprouting angiogenesis; IDA:BHF-UCL.
 GO:0003130; P:BMP signaling pathway involved in heart induction; IMP:BHF-UCL.
 GO:0071893; P:BMP signaling pathway involved in nephric duct formation; IDA:UniProtKB.
 GO:0061151; P:BMP signaling pathway involved in renal system segmentation; ISS:UniProtKB.
 GO:0061149; P:BMP signaling pathway involved in ureter morphogenesis; ISS:UniProtKB.
 GO:0060442; P:branching involved in prostate gland morphogenesis; IEA:Compara.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; IDA:UniProtKB.
 GO:0060433; P:bronchus development; IDA:MGI.
 GO:0060503; P:bud dilation involved in lung branching; IDA:MGI.
 GO:0060449; P:bud elongation involved in lung branching; IEA:Compara.
 GO:0055007; P:cardiac muscle cell differentiation; IEA:Compara.
 GO:0003279; P:cardiac septum development; TAS:BHF-UCL.
 GO:0071363; P:cellular response to growth factor stimulus; IEA:Compara.
 GO:0002062; P:chondrocyte differentiation; ISS:UniProtKB.
 GO:0060197; P:cloacal septation; IEA:Compara.
 GO:0007182; P:common-partner SMAD protein phosphorylation; IDA:UniProtKB.
 GO:0060363; P:cranial suture morphogenesis; IEA:Compara.
 GO:0035993; P:deltoid tuberosity development; ISS:UniProtKB.
 GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Compara.
 GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Compara.
 GO:0042733; P:embryonic digit morphogenesis; IEA:Compara.
 GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Compara.
 GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Compara.
 GO:0003197; P:endocardial cushion development; TAS:BHF-UCL.
 GO:0001958; P:endochondral ossification; ISS:UniProtKB.
 GO:0060502; P:epithelial cell proliferation involved in lung morphogenesis; IDA:MGI.
 GO:0060684; P:epithelial-mesenchymal cell signaling; IEA:Compara.
 GO:0030218; P:erythrocyte differentiation; IEA:Compara.
 GO:0030198; P:extracellular matrix organization; TAS:Reactome.
 GO:0007281; P:germ cell development; IEA:Compara.
 GO:0072104; P:glomerular capillary formation; ISS:UniProtKB.
 GO:0072015; P:glomerular visceral epithelial cell development; IEA:Compara.
 GO:0060113; P:inner ear receptor cell differentiation; IEA:Compara.
 GO:0048392; P:intermediate mesodermal cell differentiation; IDA:UniProtKB.
 GO:0060235; P:lens induction in camera-type eye; IEA:Compara.
 GO:0048286; P:lung alveolus development; IDA:MGI.
 GO:0002320; P:lymphoid progenitor cell differentiation; IMP:BHF-UCL.
 GO:0030225; P:macrophage differentiation; IDA:DFLAT.
 GO:0060592; P:mammary gland formation; IEA:Compara.
 GO:0072161; P:mesenchymal cell differentiation involved in kidney development; IEA:Compara.
 GO:0072198; P:mesenchymal cell proliferation involved in ureter development; IEA:Compara.
 GO:0072138; P:mesenchymal cell proliferation involved in ureteric bud development; IEA:Compara.
 GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; IDA:UniProtKB.
 GO:0007500; P:mesodermal cell fate determination; IEA:Compara.
 GO:0001823; P:mesonephros development; IEP:UniProtKB.
 GO:0072205; P:metanephric collecting duct development; ISS:UniProtKB.
 GO:0030224; P:monocyte differentiation; IDA:DFLAT.
 GO:0072097; P:negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway; IDA:UniProtKB.
 GO:0090191; P:negative regulation of branching involved in ureteric bud morphogenesis; IDA:UniProtKB.
 GO:2000137; P:negative regulation of cell proliferation involved in heart morphogenesis; IMP:BHF-UCL.
 GO:0032331; P:negative regulation of chondrocyte differentiation; IEA:Compara.
 GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Compara.
 GO:0072125; P:negative regulation of glomerular mesangial cell proliferation; IDA:UniProtKB.
 GO:0090194; P:negative regulation of glomerulus development; IDA:UniProtKB.
 GO:0033088; P:negative regulation of immature T cell proliferation in thymus; IMP:BHF-UCL.
 GO:0043407; P:negative regulation of MAP kinase activity; IDA:UniProtKB.
 GO:0072200; P:negative regulation of mesenchymal cell proliferation involved in ureter development; IDA:UniProtKB.
 GO:2000007; P:negative regulation of metanephric comma-shaped body morphogenesis; IDA:UniProtKB.
 GO:2000005; P:negative regulation of metanephric S-shaped body morphogenesis; IDA:UniProtKB.
 GO:0045839; P:negative regulation of mitosis; IDA:UniProtKB.
 GO:0045662; P:negative regulation of myoblast differentiation; IDA:MGI.
 GO:0060686; P:negative regulation of prostatic bud formation; IEA:Compara.
 GO:0045843; P:negative regulation of striated muscle tissue development; IDA:MGI.
 GO:0033085; P:negative regulation of T cell differentiation in thymus; IMP:BHF-UCL.
 GO:0070244; P:negative regulation of thymocyte apoptotic process; IMP:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0001843; P:neural tube closure; IEA:Compara.
 GO:0048663; P:neuron fate commitment; IEA:Compara.
 GO:0042476; P:odontogenesis; IGI:UniProtKB.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Compara.
 GO:0001649; P:osteoblast differentiation; IDA:BHF-UCL.
 GO:0021983; P:pituitary gland development; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
 GO:0030513; P:positive regulation of BMP signaling pathway; ISS:UniProtKB.
 GO:0030501; P:positive regulation of bone mineralization; IDA:UniProtKB.
 GO:0061047; P:positive regulation of branching involved in lung morphogenesis; ISS:UniProtKB.
 GO:0055020; P:positive regulation of cardiac muscle fiber development; IMP:BHF-UCL.
 GO:0061036; P:positive regulation of cartilage development; IDA:MGI.
 GO:0032967; P:positive regulation of collagen biosynthetic process; IDA:BHF-UCL.
 GO:2000105; P:positive regulation of DNA-dependent DNA replication; IDA:BHF-UCL.
 GO:0045603; P:positive regulation of endothelial cell differentiation; IEA:Compara.
 GO:0010595; P:positive regulation of endothelial cell migration; IDA:UniProtKB.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:UniProtKB.
 GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Compara.
 GO:0090184; P:positive regulation of kidney development; IDA:UniProtKB.
 GO:0045666; P:positive regulation of neuron differentiation; IEA:Compara.
 GO:0045669; P:positive regulation of osteoblast differentiation; IDA:BHF-UCL.
 GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IDA:UniProtKB.
 GO:0060391; P:positive regulation of SMAD protein import into nucleus; IDA:BHF-UCL.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IDA:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0009791; P:post-embryonic development; IDA:MGI.
 GO:0034504; P:protein localization to nucleus; IDA:UniProtKB.
 GO:0061155; P:pulmonary artery endothelial tube morphogenesis; IDA:UniProtKB.
 GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; IEA:Compara.
 GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; IEA:Compara.
 GO:0051150; P:regulation of smooth muscle cell differentiation; IEA:Compara.
 GO:0003014; P:renal system process; IEA:Compara.
 GO:0003139; P:secondary heart field specification; IMP:BHF-UCL.
 GO:0060395; P:SMAD protein signal transduction; IDA:UniProtKB.
 GO:0007224; P:smoothened signaling pathway; IEP:UniProtKB.
 GO:0010159; P:specification of organ position; IEA:Compara.
 GO:0072101; P:specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway; IDA:UniProtKB.
 GO:0043401; P:steroid hormone mediated signaling pathway; IMP:UniProtKB.
 GO:0021537; P:telencephalon development; IDA:MGI.
 GO:0021978; P:telencephalon regionalization; IEA:Compara.
 GO:0035990; P:tendon cell differentiation; ISS:UniProtKB.
 GO:0060438; P:trachea development; IDA:MGI.
 GO:0060440; P:trachea formation; IEA:Compara.
 GO:0003323; P:type B pancreatic cell development; IDA:BHF-UCL.
 GO:0072192; P:ureter epithelial cell differentiation; ISS:UniProtKB.
 GO:0072193; P:ureter smooth muscle cell differentiation; ISS:UniProtKB. 
Interpro
 IPR001839; TGF-b_C.
 IPR001111; TGF-b_N.
 IPR015615; TGF-beta-rel.
 IPR017948; TGFb_CS. 
Pfam
 PF00019; TGF_beta
 PF00688; TGFb_propeptide 
SMART
 SM00204; TGFB 
PROSITE
 PS00250; TGF_BETA_1
 PS51362; TGF_BETA_2 
PRINTS