CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033543
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Integrin beta 
Protein Synonyms/Alias
  
Gene Name
 ITGB1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
50KGTAEKLKPEDITQIubiquitination[1]
77EPQTFTLKFKRAEDYubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Cell adhesion; Complete proteome; Integrin; Membrane; Reference proteome; Transmembrane. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 98 AA 
Protein Sequence
MPTSARCDDL EALKKKGCPP DDIENPRGSK DIKKNKNVTN RSKGTAEKLK PEDITQIQPQ 60
QLVLRLRSGE PQTFTLKFKR AEDYPIDLYY LMDLSYSM 98 
Gene Ontology
 GO:0001669; C:acrosomal vesicle; IEA:Compara.
 GO:0034667; C:alpha3-beta1 integrin complex; IEA:Compara.
 GO:0034679; C:alpha9-beta1 integrin complex; IEA:Compara.
 GO:0005604; C:basement membrane; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005925; C:focal adhesion; IEA:Compara.
 GO:0030056; C:hemidesmosome; IEA:Compara.
 GO:0014704; C:intercalated disc; IEA:Compara.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0035748; C:myelin sheath abaxonal region; IEA:Compara.
 GO:0031594; C:neuromuscular junction; IEA:Compara.
 GO:0042383; C:sarcolemma; IEA:Compara.
 GO:0042277; F:peptide binding; IEA:Compara.
 GO:0004872; F:receptor activity; IEA:InterPro.
 GO:0055007; P:cardiac muscle cell differentiation; IEA:Compara.
 GO:0001708; P:cell fate specification; IEA:Compara.
 GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Compara.
 GO:0007160; P:cell-matrix adhesion; IEA:Compara.
 GO:0006874; P:cellular calcium ion homeostasis; IEA:Compara.
 GO:0071479; P:cellular response to ionizing radiation; IEA:Compara.
 GO:0071260; P:cellular response to mechanical stimulus; IEA:Compara.
 GO:0071305; P:cellular response to vitamin D; IEA:Compara.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Compara.
 GO:0008354; P:germ cell migration; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0060135; P:maternal process involved in female pregnancy; IEA:Compara.
 GO:0031345; P:negative regulation of cell projection organization; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0045665; P:negative regulation of neuron differentiation; IEA:Compara.
 GO:0031175; P:neuron projection development; IEA:Compara.
 GO:0030335; P:positive regulation of cell migration; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Compara.
 GO:0045807; P:positive regulation of endocytosis; IEA:Compara.
 GO:0043410; P:positive regulation of MAPK cascade; IEA:Compara.
 GO:0045666; P:positive regulation of neuron differentiation; IEA:Compara.
 GO:0010976; P:positive regulation of neuron projection development; IEA:Compara.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Compara.
 GO:0032594; P:protein transport within lipid bilayer; IEA:Compara.
 GO:0051726; P:regulation of cell cycle; IEA:Compara.
 GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IEA:Compara.
 GO:0014823; P:response to activity; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0034698; P:response to gonadotropin stimulus; IEA:Compara.
 GO:0071559; P:response to transforming growth factor beta stimulus; IEA:Compara.
 GO:0045214; P:sarcomere organization; IEA:Compara.
 GO:0070830; P:tight junction assembly; IEA:Compara.
 GO:0001894; P:tissue homeostasis; IEA:Compara. 
Interpro
 IPR027071; Integrin_beta-1.
 IPR015812; Integrin_bsu.
 IPR002369; Integrin_bsu_N. 
Pfam
 PF00362; Integrin_beta 
SMART
 SM00187; INB 
PROSITE
  
PRINTS
 PR01186; INTEGRINB.