| Tag | Content |
|---|
| CPLM ID | CPLM-002213 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Fructose-bisphosphate aldolase A |
Protein Synonyms/Alias | Aldolase 1; Muscle-type aldolase |
Gene Name | Aldoa |
Gene Synonyms/Alias | Aldo1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 147 | KDGADFAKWRCVLKI | acetylation | [1] |
|
Reference | [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ. Mol Cell. 2013 Jan 10;49(1):186-99. [ PMID: 23201123] |
Functional Description | Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). |
Sequence Annotation | ACT_SITE 188 188 Proton acceptor (By similarity).
ACT_SITE 230 230 Schiff-base intermediate with
BINDING 56 56 Substrate.
BINDING 147 147 Substrate.
MOD_RES 5 5 Phosphotyrosine (By similarity).
MOD_RES 9 9 Phosphothreonine (By similarity).
MOD_RES 13 13 N6-acetyllysine (By similarity).
MOD_RES 36 36 Phosphoserine.
MOD_RES 37 37 Phosphothreonine (By similarity).
MOD_RES 39 39 Phosphoserine.
MOD_RES 42 42 N6-acetyllysine (By similarity).
MOD_RES 46 46 Phosphoserine.
MOD_RES 65 65 Phosphothreonine (By similarity).
MOD_RES 108 108 N6-acetyllysine (By similarity).
MOD_RES 111 111 N6-malonyllysine (By similarity).
MOD_RES 174 174 Nitrated tyrosine.
MOD_RES 204 204 Phosphotyrosine (By similarity).
MOD_RES 223 223 Phosphotyrosine (By similarity).
MOD_RES 235 235 Phosphothreonine (By similarity).
MOD_RES 241 241 Phosphothreonine (By similarity).
MOD_RES 312 312 N6-malonyllysine (By similarity).
MOD_RES 330 330 N6-acetyllysine (By similarity).
MOD_RES 354 354 Phosphoserine (By similarity).
MOD_RES 356 356 Phosphoserine (By similarity).
MOD_RES 364 364 Phosphotyrosine (By similarity). |
Keyword | Acetylation; Complete proteome; Direct protein sequencing; Glycolysis; Lyase; Nitration; Phosphoprotein; Reference proteome; Schiff base. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 364 AA |
Protein Sequence | MPHPYPALTP EQKKELSDIA HRIVAPGKGI LAADESTGSI AKRLQSIGTE NTEENRRFYR 60
QLLLTADDRV NPCIGGVILF HETLYQKADD GRPFPQVIKS KGGVVGIKVD KGVVPLAGTN 120
GETTTQGLDG LSERCAQYKK DGADFAKWRC VLKIGEHTPS ALAIMENANV LARYASICQQ 180
NGIVPIVEPE ILPDGDHDLK RCQYVTEKVL AAVYKALSDH HVYLEGTLLK PNMVTPGHAC 240
TQKFSNEEIA MATVTALRRT VPPAVTGVTF LSGGQSEEEA SINLNAINKC PLLKPWALTF 300
SYGRALQASA LKAWGGKKEN LKAAQEEYIK RALANSLACQ GKYTPSGQSG AAASESLFIS 360
NHAY 364 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |