UniProt Accession

 UFD1_YEAST; P53044; D6VUI5; Q45U36 

Genbank Protein ID

 U22153; U17264; DQ115391; Z72833; AY692806; BK006941 

Genbank Nucleotide ID

 AAC49023.1; AAB46627.1; AAZ22463.1; CAA97047.1; AAT92825.1; DAA08146.1 

Protein Name

 Ubiquitin fusion degradation protein 1 

Protein Synonyms/Alias

 UB fusion protein 1; Polymerase-interacting protein 3 

Gene Name

 UFD1 

Gene Synonyms/Alias

 PIP3; YGR048W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
70	IRYPMLFKLTANETG	ubiquitination	[1]
177	KIKILEVKPESSSKS	ubiquitination	[1]
224	EKKNSFGKGQVLDPS	ubiquitination	[1]
257	SSRNKLSKFVGQGQN	ubiquitination	[1]
268	QGQNISGKAPKAEPK	ubiquitination	[1]
319	EESAAGSKSSEQNFQ	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Required for the proteasome-dependent processing/activation of MGA2 and SPT23 transcription factors leading to the subsequent expression of OLE1. Has an additional role in the turnover of OLE1 where it targets ubiquitinated OLE1 and other proteins to the ERAD. 

Sequence Annotation

 REGION 27 28 Monoubiquitin-binding.
 REGION 30 32 Monoubiquitin-binding.
 REGION 99 101 Monoubiquitin-binding.
 MOD_RES 354 354 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Phosphoprotein; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 361 AA 

Protein Sequence

Gene Ontology

 GO:0034098; C:Cdc48p-Npl4p-Ufd1p AAA ATPase complex; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0031593; F:polyubiquitin binding; IDA:SGD.
 GO:0071629; P:cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process; IMP:SGD.
 GO:0071712; P:ER-associated misfolded protein catabolic process; IMP:SGD.
 GO:1900182; P:positive regulation of protein localization to nucleus; IMP:SGD.
 GO:0030970; P:retrograde protein transport, ER to cytosol; IMP:SGD. 

Interpro

 IPR004854; UFD1. 

Pfam

 PF03152; UFD1 

SMART

  

PROSITE

  

PRINTS