CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004667
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acetylornithine/succinyldiaminopimelate aminotransferase 
Protein Synonyms/Alias
 ACOAT; DapATase; Succinyldiaminopimelate transferase 
Gene Name
 argD 
Gene Synonyms/Alias
 dapC; dtu; b3359; JW3322 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
30PAEFIPVKGQGSRIWacetylation[1]
92PALRLGRKLIEATFAacetylation[1]
156VSVGGQPKYSDGFGPacetylation[1]
324RFVDHLQKIDQQYDVacetylation[1]
347LLIGAELKPQYKGRAacetylation[1]
402RFAHAVAKVVGA***acetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Involved in both the arginine and lysine biosynthetic pathways. 
Sequence Annotation
 REGION 108 109 Pyridoxal phosphate binding (By
 REGION 226 229 Pyridoxal phosphate binding (By
 BINDING 141 141 Pyridoxal phosphate; via carbonyl oxygen
 BINDING 144 144 N2-acetyl-L-ornithine (By similarity).
 BINDING 283 283 N2-acetyl-L-ornithine (By similarity).
 BINDING 284 284 Pyridoxal phosphate (By similarity).
 MOD_RES 255 255 N6-(pyridoxal phosphate)lysine (By  
Keyword
 Amino-acid biosynthesis; Aminotransferase; Arginine biosynthesis; Complete proteome; Cytoplasm; Direct protein sequencing; Lysine biosynthesis; Pyridoxal phosphate; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 406 AA 
Protein Sequence
MAIEQTAITR ATFDEVILPI YAPAEFIPVK GQGSRIWDQQ GKEYVDFAGG IAVTALGHCH 60
PALVNALKTQ GETLWHISNV FTNEPALRLG RKLIEATFAE RVVFMNSGTE ANETAFKLAR 120
HYACVRHSPF KTKIIAFHNA FHGRSLFTVS VGGQPKYSDG FGPKPADIIH VPFNDLHAVK 180
AVMDDHTCAV VVEPIQGEGG VTAATPEFLQ GLRELCDQHQ ALLVFDEVQC GMGRTGDLFA 240
YMHYGVTPDI LTSAKALGGG FPISAMLTTA EIASAFHPGS HGSTYGGNPL ACAVAGAAFD 300
IINTPEVLEG IQAKRQRFVD HLQKIDQQYD VFSDIRGMGL LIGAELKPQY KGRARDFLYA 360
GAEAGVMVLN AGPDVMRFAP SLVVEDADID EGMQRFAHAV AKVVGA 406 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003992; F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity; IDA:EcoliWiki.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0009016; F:succinyldiaminopimelate transaminase activity; IDA:EcoliWiki.
 GO:0006526; P:arginine biosynthetic process; IDA:EcoCyc.
 GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway. 
Interpro
 IPR017652; Ac/SucOrn_transaminase_bac.
 IPR005814; Aminotrans_3.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR004636; Trfase_AcOrn/SuccOrn_fam. 
Pfam
 PF00202; Aminotran_3 
SMART
  
PROSITE
 PS00600; AA_TRANSFER_CLASS_3 
PRINTS