CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013270
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 26S proteasome non-ATPase regulatory subunit 2 
Protein Synonyms/Alias
  
Gene Name
 Psmd2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
105FLRPHYGKLKEIYENacetylation[1]
343ELDIMEPKVPDDIYKacetylation[1]
397LLTDDGNKWLYKNKDacetylation[1]
754QLAQYHAKDPNNLFMacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins (By similarity). 
Sequence Annotation
 REPEAT 409 442 PC 1.
 REPEAT 443 479 PC 2.
 REPEAT 480 514 PC 3.
 REPEAT 517 551 PC 4.
 REPEAT 560 589 PC 5.
 REPEAT 692 723 PC 6.
 REPEAT 742 757 PC 7.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 17 17 Phosphoserine (By similarity).
 MOD_RES 22 22 Phosphoserine (By similarity).
 MOD_RES 29 29 Phosphoserine (By similarity).
 MOD_RES 194 194 Phosphotyrosine (By similarity).
 MOD_RES 361 361 Phosphoserine (By similarity).  
Keyword
 Acetylation; Complete proteome; Phosphoprotein; Proteasome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 908 AA 
Protein Sequence
MEEGGRDKTP VQSQQPSATA PSGADEKSSG KERRDAGEKD KEQELSEEDK QLQDELEMLV 60
ERLGEKDTSL YRPALEELRR QIRSSTTSMT SVPKPLKFLR PHYGKLKEIY ENMAPGENKC 120
FAADIISVLA MTMSGERECL KYRLVGSQEE LASWGHEYVR HLAGEVAKEW QELDDAEKAQ 180
REPLLTLVKE IVPYNMAHNA EHEACDLLME IEQVDMLEKD IDENAYSKVC LYLTSCVNYV 240
PEPENSALLR CALGVFRKFS RFPEALRLAL MLNDMELVED IFTSCKDVVV QKQMAFMLGR 300
HGVFLELSED VEEYEDLTEI MSNVQLNSNF LALARELDIM EPKVPDDIYK THLENNRFGG 360
SGSQVDSARM NLASSFVNGF VNAAFGQDKL LTDDGNKWLY KNKDHGMLSA AASLGMILLW 420
DVDGGLTQID KYLYSSEDYI KSGALLACGI VNSGVRNECD PALALLSDYV LHNSNTMRLG 480
SIFGLGLAYA GSNREDVLTL LLPVMGDSKS SMEVAGVTAL ACGMIAVGSC NGDVTSTILQ 540
TIMEKSETEL KDTYARWLPL GLGLNHLGKG EAIEAILAAL EVVSEPFRSF ANTLVDVCAY 600
AGSGNVLKVQ QLLHICSEHF DSKEKEEDKD KKEKKDKDKK EAPADMGAHQ GVAVLGIALI 660
AMGEEIGAEM ALRTFGHLLR YGEPTLRRAV PLALALISVS NPRLNILDTL SKFSHDADPE 720
VSYNSIFAMG MVGSGTNNAR LAAMLRQLAQ YHAKDPNNLF MVRLAQGLTH LGKGTLTLCP 780
YHSDRQLMSQ VAVAGLLTVL VSFLDVRNII LGKSHYVLYG LVAAMQPRML VTFDEELRPL 840
PVSVRVGQAV DVVGQAGKPK TITGFQTHTT PVLLAHGERA ELATEEFLPV TPILEGFVIL 900
RKNPNYNL 908 
Gene Ontology
 GO:0022624; C:proteasome accessory complex; ISS:UniProtKB.
 GO:0030234; F:enzyme regulator activity; IEA:InterPro.
 GO:0050790; P:regulation of catalytic activity; IEA:GOC.
 GO:0042176; P:regulation of protein catabolic process; IEA:InterPro. 
Interpro
 IPR016643; 26S_Psome_Rpn1.
 IPR002015; APC_proteasome.
 IPR016024; ARM-type_fold. 
Pfam
 PF01851; PC_rep 
SMART
  
PROSITE
  
PRINTS