UniProt Accession

 CCNB1_RAT; P30277 

Genbank Protein ID

 X60768; X64589; L11995; BC059113 

Genbank Nucleotide ID

 CAA43178.1; CAA45877.1; AAC00032.1; AAH59113.1 

Protein Name

 G2/mitotic-specific cyclin-B1 

Protein Synonyms/Alias

  

Gene Name

 Ccnb1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
35	PVAVAASKPLLRSRT	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Essential for the control of the cell cycle at the G2/M (mitosis) transition. 

Sequence Annotation

 REGION 159 167 Interaction with CDK2 (By similarity).
 REGION 248 251 Interaction with CDK2 (By similarity).
 MOD_RES 116 116 Phosphoserine; by CDK1 (By similarity).
 MOD_RES 118 118 Phosphoserine (By similarity).
 MOD_RES 123 123 Phosphoserine; by PLK1 (By similarity).
 MOD_RES 137 137 Phosphoserine (By similarity).
 MOD_RES 311 311 Phosphothreonine (By similarity).  

Keyword

 Cell cycle; Cell division; Complete proteome; Cyclin; Cytoplasm; Cytoskeleton; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 423 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; ISS:UniProtKB.
 GO:0000942; C:condensed nuclear chromosome outer kinetochore; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0000922; C:spindle pole; IEA:Compara.
 GO:0016301; F:kinase activity; IEA:Compara.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0071398; P:cellular response to fatty acid; IEP:RGD.
 GO:0071456; P:cellular response to hypoxia; IEP:RGD.
 GO:0071283; P:cellular response to iron(III) ion; IEP:RGD.
 GO:0071407; P:cellular response to organic cyclic compound; IEP:RGD.
 GO:0048565; P:digestive tract development; IEP:RGD.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0000278; P:mitotic cell cycle; IEP:RGD.
 GO:0007080; P:mitotic metaphase plate congression; IEA:Compara.
 GO:0071174; P:mitotic spindle checkpoint; IEA:Compara.
 GO:0043148; P:mitotic spindle stabilization; IEA:Compara.
 GO:0010629; P:negative regulation of gene expression; IMP:RGD.
 GO:0001933; P:negative regulation of protein phosphorylation; IMP:RGD.
 GO:0001556; P:oocyte maturation; IMP:RGD.
 GO:0051987; P:positive regulation of attachment of spindle microtubules to kinetochore; IEA:Compara.
 GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IDA:RGD.
 GO:0033129; P:positive regulation of histone phosphorylation; IMP:RGD.
 GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Compara.
 GO:0031442; P:positive regulation of mRNA 3'-end processing; IMP:RGD.
 GO:0006461; P:protein complex assembly; IDA:RGD.
 GO:0006468; P:protein phosphorylation; IEA:Compara.
 GO:0051726; P:regulation of cell cycle; IEP:RGD.
 GO:0060623; P:regulation of chromosome condensation; IMP:RGD.
 GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:InterPro.
 GO:0046680; P:response to DDT; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0009612; P:response to mechanical stimulus; IEP:RGD.
 GO:0007283; P:spermatogenesis; IEP:RGD.
 GO:0042246; P:tissue regeneration; IEP:RGD.
 GO:0055015; P:ventricular cardiac muscle cell development; IEP:RGD. 

Interpro

 IPR013763; Cyclin-like.
 IPR014400; Cyclin_A/B/D/E.
 IPR004367; Cyclin_C-dom.
 IPR006671; Cyclin_N. 

Pfam

 PF02984; Cyclin_C
 PF00134; Cyclin_N 

SMART

 SM00385; CYCLIN 

PROSITE

 PS00292; CYCLINS 

PRINTS