| Tag | Content |
|---|
| CPLM ID | CPLM-010785 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 |
Protein Synonyms/Alias | Phosphoinositide phospholipase C-beta-2; Phospholipase C-beta-2; PLC-beta-2 |
Gene Name | PLCB2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 761 | AVMEEGNKFLGHRII | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. |
Sequence Annotation | DOMAIN 312 463 PI-PLC X-box.
DOMAIN 546 662 PI-PLC Y-box.
DOMAIN 669 767 C2.
ACT_SITE 327 327 By similarity.
ACT_SITE 374 374 By similarity.
METAL 328 328 Calcium.
METAL 357 357 Calcium.
METAL 359 359 Calcium.
METAL 408 408 Calcium. |
Keyword | 3D-structure; Alternative splicing; Calcium; Coiled coil; Complete proteome; Hydrolase; Lipid degradation; Lipid metabolism; Metal-binding; Polymorphism; Reference proteome; Transducer. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1185 AA |
Protein Sequence | MSLLNPVLLP PKVKAYLSQG ERFIKWDDET TVASPVILRV DPKGYYLYWT YQSKEMEFLD 60
ITSIRDTRFG KFAKMPKSQK LRDVFNMDFP DNSFLLKTLT VVSGPDMVDL TFHNFVSYKE 120
NVGKAWAEDV LALVKHPLTA NASRSTFLDK ILVKLKMQLN SEGKIPVKNF FQMFPADRKR 180
VEAALSACHL PKGKNDAINP EDFPEPVYKS FLMSLCPRPE IDEIFTSYHA KAKPYMTKEH 240
LTKFINQKQR DSRLNSLLFP PARPDQVQGL IDKYEPSGIN AQRGQLSPEG MVWFLCGPEN 300
SVLAQDKLLL HHDMTQPLNH YFINSSHNTY LTAGQFSGLS SAEMYRQVLL SGCRCVELDC 360
WKGKPPDEEP IITHGFTMTT DIFFKEAIEA IAESAFKTSP YPIILSFENH VDSPRQQAKM 420
AEYCRTIFGD MLLTEPLEKF PLKPGVPLPS PEDLRGKILI KNKKNQFSGP TSSSKDTGGE 480
AEGSSPPSAP AGEGTVWAGE EGTELEEEEV EEEEEEESGN LDEEEIKKMQ SDEGTAGLEV 540
TAYEEMSSLV NYIQPTKFVS FEFSAQKNRS YVISSFTELK AYDLLSKASV QFVDYNKRQM 600
SRIYPKGTRM DSSNYMPQMF WNAGCQMVAL NFQTMDLPMQ QNMAVFEFNG QSGYLLKHEF 660
MRRPDKQFNP FSVDRIDVVV ATTLSITVIS GQFLSERSVR TYVEVELFGL PGDPKRRYRT 720
KLSPSTNSIN PVWKEEPFVF EKILMPELAS LRVAVMEEGN KFLGHRIIPI NALNSGYHHL 780
CLHSESNMPL TMPALFIFLE MKDYIPGAWA DLTVALANPI KFFSAHDTKS VKLKEAMGGL 840
PEKPFPLASP VASQVNGALA PTSNGSPAAR AGAREEAMKE AAEPRTASLE ELRELKGVVK 900
LQRRHEKELR ELERRGARRW EELLQRGAAQ LAELGPPGVG GVGACKLGPG KGSRKKRSLP 960
REESAGAAPG EGPEGVDGRV RELKDRLELE LLRQGEEQYE CVLKRKEQHV AEQISKMMEL 1020
AREKQAAELK ALKETSENDT KEMKKKLETK RLERIQGMTK VTTDKMAQER LKREINNSHI 1080
QEVVQVIKQM TENLERHQEK LEEKQAACLE QIREMEKQFQ KEALAEYEAR MKGLEAEVKE 1140
SVRACLRTCF PSEAKDKPER ACECPPELCE QDPLIAKADA QESRL 1185 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0004435; F:phosphatidylinositol phospholipase C activity; TAS:ProtInc. GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. GO:0007202; P:activation of phospholipase C activity; TAS:ProtInc. GO:0043647; P:inositol phosphate metabolic process; TAS:Reactome. GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. GO:0006644; P:phospholipid metabolic process; TAS:ProtInc. GO:0050913; P:sensory perception of bitter taste; IEA:Compara. GO:0007268; P:synaptic transmission; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |