UniProt Accession

 KAD_MYCTU; P69440; L0T7C0; O53796; P94927 

Genbank Protein ID

 AE000516; AL123456 

Genbank Nucleotide ID

 AAK44991.1; CCP43478.1 

Protein Name

 Adenylate kinase 

Protein Synonyms/Alias

 AK; ATP-AMP transphosphorylase; ATP:AMP phosphotransferase; Adenylate monophosphate kinase 

Gene Name

 adk 

Gene Synonyms/Alias

 Rv0733; MT0757; MTV041.07 

Created Date

 July 27, 2013 

Organism

 Mycobacterium tuberculosis 

NCBI Taxa ID

 1773 

Lysine Modification

Position	Peptide	Type	References
94	PRSVEQAKALHEMLE	pupylation	[1]

Reference

 [1] Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] .
 Festa RA, McAllister F, Pearce MJ, Mintseris J, Burns KE, Gygi SP, Darwin KH.
 PLoS One. 2010 Jan 6;5(1):e8589. [PMID: 20066036] 

Functional Description

 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Has a broad specificity for nucleoside triphosphates, being highly active with ATP or dATP as phosphate donors, and less active with GTP or UTP. 

Sequence Annotation

 NP_BIND 10 15 ATP.
 NP_BIND 57 59 AMP.
 NP_BIND 85 88 AMP.
 REGION 30 59 NMPbind.
 REGION 126 132 LID.
 BINDING 31 31 AMP.
 BINDING 36 36 AMP.
 BINDING 92 92 AMP.
 BINDING 127 127 ATP.
 BINDING 129 129 AMP.
 BINDING 140 140 AMP.
 BINDING 166 166 ATP; via carbonyl oxygen.
 CROSSLNK 94 94 Isoglutamyl lysine isopeptide (Lys-Gln)  

Keyword

 3D-structure; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Isopeptide bond; Kinase; Nucleotide biosynthesis; Nucleotide-binding; Reference proteome; Transferase; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 181 AA 

Protein Sequence

Gene Ontology

 GO:0005618; C:cell wall; IDA:MTBBASE.
 GO:0005829; C:cytosol; IDA:MTBBASE.
 GO:0005886; C:plasma membrane; IDA:MTBBASE.
 GO:0004017; F:adenylate kinase activity; IDA:MTBBASE.
 GO:0005524; F:ATP binding; IDA:MTBBASE.
 GO:0004550; F:nucleoside diphosphate kinase activity; IDA:MTBBASE.
 GO:0044209; P:AMP salvage; IDA:MTBBASE.
 GO:0009141; P:nucleoside triphosphate metabolic process; IDA:MTBBASE.
 GO:0006144; P:purine nucleobase metabolic process; IDA:MTBBASE. 

Interpro

 IPR000850; Adenylate_kin.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00406; ADK 

SMART

  

PROSITE

 PS00113; ADENYLATE_KINASE 

PRINTS

 PR00094; ADENYLTKNASE.