CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010371
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 L-lactate dehydrogenase 
Protein Synonyms/Alias
 L-LDH 
Gene Name
 ldh 
Gene Synonyms/Alias
 MPN_674; MP168 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
67KVIAGDYKQLKDYDFacetylation[1]
70AGDYKQLKDYDFIFIacetylation[1]
161LKFAIAEKYGMSSRDacetylation[1]
196KIAGLPLKHFSKASDacetylation[1]
200LPLKHFSKASDIEKEacetylation[1]
206SKASDIEKEFAEIDHacetylation[1]
298TEKAGLDKSIQVLKDacetylation[1]
304DKSIQVLKDNIKLAKacetylation[1]
308QVLKDNIKLAKL***acetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
  
Sequence Annotation
 NP_BIND 12 40 NAD (By similarity).
 ACT_SITE 177 177 Proton acceptor (By similarity).
 BINDING 90 90 Substrate (By similarity).
 BINDING 122 122 NAD or substrate (By similarity).
 BINDING 153 153 Substrate (By similarity).
 BINDING 229 229 Substrate (By similarity).
 MOD_RES 220 220 Phosphotyrosine (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 312 AA 
Protein Sequence
MKSLKVALIG SGAVGTSFLY AAMSRGLASE YMVIDINEKS QVGNVFDLQD AVPSSPQYSK 60
VIAGDYKQLK DYDFIFIGAG RPQKQGGETR LQLLEGNVEI MKNIAKAVKE SGFKGITLIA 120
SNPVDIMAYT YLKVTGFEPN KVIGSGTLLD SARLKFAIAE KYGMSSRDVQ AYVLGEHGDS 180
SVSIISSAKI AGLPLKHFSK ASDIEKEFAE IDHFIRRRAY EIIERKGATF YGIGEATAEV 240
AELILRDTKE VRVVASLING QYGAKDVMFG TPCVLGRNGV EKILEIELSA TEKAGLDKSI 300
QVLKDNIKLA KL 312 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004459; F:L-lactate dehydrogenase activity; IEA:HAMAP.
 GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
 GO:0006096; P:glycolysis; IEA:HAMAP. 
Interpro
 IPR001557; L-lactate/malate_DH.
 IPR011304; L-lactate_DH.
 IPR018177; L-lactate_DH_AS.
 IPR022383; Lactate/malate_DH_C.
 IPR001236; Lactate/malate_DH_N.
 IPR015955; Lactate_DH/Glyco_Ohase_4_C.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF02866; Ldh_1_C
 PF00056; Ldh_1_N 
SMART
  
PROSITE
 PS00064; L_LDH 
PRINTS
 PR00086; LLDHDRGNASE.