CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011564
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Adenylyl cyclase-associated protein 1 
Protein Synonyms/Alias
 CAP 1 
Gene Name
 Cap1 
Gene Synonyms/Alias
 Cap; Mch1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
62AEYLKMSKEIGGDVQacetylation[1]
70EIGGDVQKHAEMVHTacetylation[1]
80EMVHTGLKLERALLVacetylation[1]
169FYTNRVLKEYRDVDKacetylation[1]
176KEYRDVDKKHVDWVRacetylation[1]
177EYRDVDKKHVDWVRAacetylation[1]
208TTGLAWSKTGPVAKEacetylation[1]
297GPVRSGPKPFSAPKPacetylation[1]
326ALLELEGKKWRVENQacetylation[1]
347VIDDTELKQVAYIYKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity (By similarity). 
Sequence Annotation
 DOMAIN 312 452 C-CAP/cofactor C-like.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 34 34 Phosphoserine (By similarity).
 MOD_RES 80 80 N6-acetyllysine (By similarity).
 MOD_RES 289 289 Phosphoserine (By similarity).
 MOD_RES 294 294 Phosphoserine (By similarity).
 MOD_RES 300 300 Phosphoserine (By similarity).
 MOD_RES 306 306 Phosphothreonine (By similarity).
 MOD_RES 307 307 Phosphoserine (By similarity).
 MOD_RES 309 309 Phosphoserine (By similarity).  
Keyword
 Acetylation; Actin-binding; Cell membrane; Complete proteome; Direct protein sequencing; Membrane; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 474 AA 
Protein Sequence
MADMQNLVER LERAVGRLEA VSHTSDMHCG YGDSPSKGAV PYVQAFDSLL ANPVAEYLKM 60
SKEIGGDVQK HAEMVHTGLK LERALLVTAS QCQQPAGNKL SDLLAPISEQ IQEVITFREK 120
NRGSKFFNHL SAVSESIQAL GWVALAAKPG PFVKEMNDAA MFYTNRVLKE YRDVDKKHVD 180
WVRAYLSIWT ELQAYIKEFH TTGLAWSKTG PVAKELSGLP SGPSVGSGPP PPPPGPPPPP 240
VPTSSGSDDS ASRSALFAQI NQGESITHAL KHVSDDMKTH KNPALKAQSG PVRSGPKPFS 300
APKPQTSPSP KPATKKEPAL LELEGKKWRV ENQENVSNLV IDDTELKQVA YIYKCVNTTL 360
QIKGKINSIT VDNCKKLGLV FDDVVGIVEI INSRDVKVQV MGKVPTISIN KTDGCHAYLS 420
KNSLDCEIVS AKSSEMNVLI PTEGGDFNEF PVPEQFKTLW NGQKLVTTVT EIAG 474 
Gene Ontology
 GO:0030864; C:cortical actin cytoskeleton; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0030036; P:actin cytoskeleton organization; IEA:Compara.
 GO:0001667; P:ameboidal cell migration; IEA:Compara.
 GO:0000902; P:cell morphogenesis; IEA:Compara.
 GO:0006898; P:receptor-mediated endocytosis; IEA:Compara. 
Interpro
 IPR001837; Adenylate_cyclase-assoc_CAP.
 IPR013912; Adenylate_cyclase-assoc_CAP_C.
 IPR013992; Adenylate_cyclase-assoc_CAP_N.
 IPR017901; C-CAP_CF_C-like.
 IPR016098; CAP/MinC_C.
 IPR018106; CAP_CS.
 IPR006599; CARP_motif. 
Pfam
 PF08603; CAP_C
 PF01213; CAP_N 
SMART
 SM00673; CARP 
PROSITE
 PS51329; C_CAP_COFACTOR_C
 PS01088; CAP_1
 PS01089; CAP_2 
PRINTS