CPLM-017587

Genbank Nucleotide ID

Estradiol 17-beta-dehydrogenase 11

Protein Synonyms/Alias

17-beta-hydroxysteroid dehydrogenase 11; 17-beta-HSD 11; 17bHSD11; 17betaHSD11; 17-beta-hydroxysteroid dehydrogenase XI; 17-beta-HSD XI; 17betaHSDXI; Cutaneous T-cell lymphoma-associated antigen HD-CL-03; CTCL-associated antigen HD-CL-03; Dehydrogenase/reductase SDR family member 8; Retinal short-chain dehydrogenase/reductase 2; retSDR2

DHRS8; PAN1B; PSEC0029; UNQ207/PRO233

Homo sapiens (Human)

Position	Peptide	Type	References
2	******MKFLLDILL	acetylation	[1]
58	LTAYEFAKLKSKLVL	ubiquitination	[2]
62	EFAKLKSKLVLWDIN	ubiquitination	[3]
70	LVLWDINKHGLEETA	acetylation	[1]
70	LVLWDINKHGLEETA	ubiquitination	[2, 4]
105	EDIYSSAKKVKAEIG	ubiquitination	[4, 5]
106	DIYSSAKKVKAEIGD	ubiquitination	[2]
227	FVNTGFIKNPSTSLG	ubiquitination	[2]

[1] Regulation of cellular metabolism by protein lysine acetylation.
Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
[2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]

Functional Description

Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma.

NP_BIND 40 64 NADP (By similarity).
ACT_SITE 185 185 Proton acceptor (By similarity).
BINDING 172 172 Substrate (By similarity).

3D-structure; Complete proteome; Lipid biosynthesis; Lipid metabolism; NADP; Oxidoreductase; Reference proteome; Secreted; Signal; Steroid biosynthesis.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0005811; C:lipid particle; IDA:UniProtKB.
GO:0004303; F:estradiol 17-beta-dehydrogenase activity; IEA:EC.
GO:0016229; F:steroid dehydrogenase activity; IDA:HGNC.
GO:0006710; P:androgen catabolic process; IDA:HGNC.
GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.

IPR002198; DH_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DH.
IPR016040; NAD(P)-bd_dom.

PR00081; GDHRDH.
PR00080; SDRFAMILY.