UniProt Accession

 FABPI_MOUSE; P55050 

Genbank Protein ID

 M65034; AK007995; BC013457 

Genbank Nucleotide ID

 AAA37589.1; BAB25397.1; AAH13457.1 

Protein Name

 Fatty acid-binding protein, intestinal 

Protein Synonyms/Alias

 Fatty acid-binding protein 2; Intestinal-type fatty acid-binding protein; I-FABP 

Gene Name

 Fabp2 

Gene Synonyms/Alias

 Fabpi 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
17	DRNENYEKFMEKMGI	ubiquitination	[1]
21	NYEKFMEKMGINVMK	ubiquitination	[1]
28	KMGINVMKRKLGAHD	ubiquitination	[1]
47	TITQDGNKFTVKESS	acetylation	[2]
47	TITQDGNKFTVKESS	succinylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. 

Sequence Annotation

 BINDING 83 83 Fatty acid (By similarity).
 BINDING 107 107 Fatty acid (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Lipid-binding; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 132 AA 

Protein Sequence

Gene Ontology

 GO:0045179; C:apical cortex; IEA:Compara.
 GO:0005622; C:intracellular; IDA:MGI.
 GO:0005902; C:microvillus; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005504; F:fatty acid binding; IEA:Compara.
 GO:0005324; F:long-chain fatty acid transporter activity; IEA:Compara.
 GO:0006631; P:fatty acid metabolic process; IEA:Compara.
 GO:0050892; P:intestinal absorption; IEA:Compara. 

Interpro

 IPR012674; Calycin.
 IPR011038; Calycin-like.
 IPR000463; Fatty_acid-bd.
 IPR000566; Lipocln_cytosolic_FA-bd_dom. 

Pfam

 PF00061; Lipocalin 

SMART

  

PROSITE

 PS00214; FABP 

PRINTS

 PR00178; FATTYACIDBP.