| Tag | Content |
|---|
| CPLM ID | CPLM-015843 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Integrator complex subunit 3 |
Protein Synonyms/Alias | Int3; SOSS complex subunit A; Sensor of single-strand DNA complex subunit A; SOSS-A; Sensor of ssDNA subunit A |
Gene Name | Ints3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 479 | APLFDNPKLDKELRS | ubiquitination | [1] | | 896 | HIKALLIKNNSLPRK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity). |
Sequence Annotation | MOD_RES 500 500 Phosphoserine (By similarity).
MOD_RES 535 535 Phosphoserine (By similarity).
MOD_RES 993 993 Phosphoserine (By similarity).
MOD_RES 1038 1038 Phosphoserine.
MOD_RES 1040 1040 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; DNA damage; DNA repair; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1041 AA |
Protein Sequence | MELQKGKGTV AAAASGAAGG GGGGAGAGAP GGGRLLLSTS LDAKDELEER LERCMSIVTS 60
MTAGVSEREA NDALNAYVCK GPPQHEEICL GLFTLVLTEP AQAQKCYRDL ALVSRDGMNI 120
VLNKINQLLM EKYLKLQDTC RTQLVWLVRE LVKSGVLGAD GVCMTFMKQI AGGDVTAKNI 180
WLAESVLDIL TEQREWVLKS SILIAMAVYT YLRLIVDHHG TAQLQTLRQK EVDFCISLLR 240
ERFMECLMIG RDLVRLLQNV ARIPEFELLW KDIIHNPQAL SPQFTGILQL LQSRTSRKFL 300
ACRLTPDMET KLLFMTSRVR FGQQKRYQDW FQRQYLSTPD SQSLRCDLIR YICGVVHPSN 360
EVLSSDILPR WAIIGWLLTT CTSNVAASNA KLALFYDWLF FSPEKDSIMN IEPAILVMHH 420
SMKPHPAITA TLLDFMCRII PNFYPPLEGH VRQGVFSSLN HIVEKRVLAH LAPLFDNPKL 480
DKELRSMLRE KFPEFCSSPS PPVEVKIEEP VSMEMDNHLS DKDESCYDNA EAAFSDDEED 540
LNSKGKKREF RFHPIKETVV EEPVDVTPYL DQLDESLRDK VLQLQKGSDT EAQCEVMQEI 600
VDQVLEEDFD SEQLSVLASC LQELFKAHFR GEVLPEEVTE ESLEESVGKP LYLIFRNLCQ 660
MQEDNSSFSL LLDLLSELYQ KQPKIGYHLL YYLRASKAAA GKMNLYESFA QATQLGDLHT 720
CLMMDMKACQ EDDVRLLCHL TPSIYTEFPD ETLRSGELLN MIVAVIDSAQ LQELVCHVMM 780
GNLVMFRKDS VLNILIQSLD WETFEQYCAW QLFLAHNIPL ETIIPILQHL KYKEHPEALS 840
CLLLQLRREK PSEEMVKMVL SRPCHPDDQF TTSILRHWCM KHDELLAEHI KALLIKNNSL 900
PRKRQSLRSS SSKLAQLTLE QILEHLDNLR LNLANTKQNF FSQTPILQAL QHVQASCDEA 960
HKMKFSDLFS LAEEYEDSST KPPKSRRKAA LSSPRSRKNA TQPPNAEEES GSSSASEEED 1020
TKPKPTKRKR KGSSAVGSDS D 1041 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |