UniProt Accession

 MS3L1_MOUSE; Q9WVG9; B1AUJ7; B1AUJ8 

Genbank Protein ID

 AF117066; AL671489; AL671489; BC010226 

Genbank Nucleotide ID

 AAD38500.2; CAM45888.1; CAM45889.1; AAH10226.1 

Protein Name

 Male-specific lethal 3 homolog 

Protein Synonyms/Alias

 Male-specific lethal-3 homolog 1; Male-specific lethal-3 protein-like 1; MSL3-like 1 

Gene Name

 Msl3 

Gene Synonyms/Alias

 Msl31; Msl3l1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
412	PIPLTPSKDGSAVFA	acetylation	[1, 2, 3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (By similarity). 

Sequence Annotation

 DOMAIN 32 90 Chromo.
 DOMAIN 172 521 MRG.
 MOD_RES 315 315 Phosphoserine (By similarity).
 MOD_RES 371 371 Phosphoserine (By similarity).
 MOD_RES 404 404 Phosphoserine (By similarity).
 MOD_RES 409 409 Phosphothreonine (By similarity).
 MOD_RES 411 411 Phosphoserine (By similarity).
 MOD_RES 415 415 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Chromatin regulator; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 525 AA 

Protein Sequence

Gene Ontology

 GO:0072487; C:MSL complex; ISS:UniProtKB.
 GO:0003677; F:DNA binding; ISS:UniProtKB.
 GO:0035064; F:methylated histone residue binding; ISS:UniProtKB.
 GO:0043984; P:histone H4-K16 acetylation; ISS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000953; Chromo_domain/shadow.
 IPR016197; Chromodomain-like.
 IPR008676; MRG.
 IPR026541; MRG_dom.
 IPR025995; Tudor-knot. 

Pfam

 PF05712; MRG
 PF11717; Tudor-knot 

SMART

 SM00298; CHROMO 

PROSITE

 PS00598; CHROMO_1
 PS50013; CHROMO_2
 PS51640; MRG 

PRINTS