CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021527
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear body protein SP140-like protein 
Protein Synonyms/Alias
  
Gene Name
 SP140L 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
173PDIKLSLKQGEVPESubiquitination[1]
207ANNSTLGKPKRKRRKubiquitination[1]
238NQQNDNSKADGQLVSubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
 DOMAIN 33 149 HSR.
 DOMAIN 293 374 SAND.
 DOMAIN 484 554 Bromo.
 ZN_FING 403 449 PHD-type.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Polymorphism; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 580 AA 
Protein Sequence
MAGGGSDLST RGLNGGVSQV ANEMNHLPAH SQSLQRLFTE DQDVDEGLVY DTVFKHFKRH 60
KLEISNAIKK TFPFLEGLRD RELITNKMFE DSEDSCRNLV PVQRVVYNVL SELEKTFNLS 120
VLEALFSEVN MQEYPDLIHI YKSFKNAIQD KLSFQESDRK EREERPDIKL SLKQGEVPES 180
PEARKESDQA CGKMDTVDIA NNSTLGKPKR KRRKKKGHGW SRMGTRTQKN NQQNDNSKAD 240
GQLVSSEKKA NMNLKDLSKI RGRKRGKPGT HFTQSDRAPQ KRVRSRGTLA KCIQTEDGKW 300
FTPMEFEIKG GYARSKNWRL SVRCGGWPLR RLMEEGSLPN PPRIYYRNKK RILKSQNNSS 360
VDPCMRNLDE CEVCRDGGEL FCCDTCSRVF HEDCHIPPVE SEKTPWNCIF CRMKESPGSQ 420
QCCQESEVLE RQMCPEEQLK CEFLLLKVYC CSESSFFAKI PYYYYIREAC QGLKEPMWLD 480
KIKKRLNEHG YPQVEGFVQD MRLIFQNHRA SYKYKDFGQM GLRLEAEFEK DFKEVFAIQE 540
TNGNS 545 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR001487; Bromodomain.
 IPR000770; SAND_dom.
 IPR010919; SAND_dom-like.
 IPR004865; Sp100.
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00439; Bromodomain
 PF00628; PHD
 PF01342; SAND
 PF03172; Sp100 
SMART
 SM00297; BROMO
 SM00249; PHD
 SM00258; SAND 
PROSITE
 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2
 PS51414; HSR
 PS50864; SAND
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 
PRINTS