UniProt Accession

 MET16_YEAST; P18408; D6W4G8; Q06212 

Genbank Protein ID

 J05591; U25840; AY693236; BK006949 

Genbank Nucleotide ID

 AAA34774.1; AAB68154.1; AAT93255.1; DAA11584.1 

Protein Name

 Phosphoadenosine phosphosulfate reductase 

Protein Synonyms/Alias

 3'-phosphoadenylylsulfate reductase; PAPS reductase, thioredoxin dependent; PAdoPS reductase 

Gene Name

 MET16 

Gene Synonyms/Alias

 YPR167C; P9325.8 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
139	DKYDYLAKVEPAHRA	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 The NADP dependent reduction of PAPS into sulfite involves thioredoxin which probably plays the role of a thiol carrier. 

Sequence Annotation

  

Keyword

 3D-structure; Amino-acid biosynthesis; Complete proteome; Cysteine biosynthesis; Methionine biosynthesis; NADP; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 261 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IC:SGD.
 GO:0004604; F:phosphoadenylyl-sulfate reductase (thioredoxin) activity; IDA:SGD.
 GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.
 GO:0070814; P:hydrogen sulfide biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
 GO:0019379; P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin); IDA:SGD.
 GO:0000096; P:sulfur amino acid metabolic process; IMP:SGD. 

Interpro

 IPR004511; PAPS/APS_Rdtase.
 IPR002500; PAPS_reduct.
 IPR011800; PAPS_reductase_CysH.
 IPR014729; Rossmann-like_a/b/a_fold. 

Pfam

 PF01507; PAPS_reduct 

SMART

  

PROSITE

  

PRINTS