CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021456
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WD repeat-containing protein 55 
Protein Synonyms/Alias
  
Gene Name
 WDR55 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
85WSSGHHLKACRAVAFubiquitination[1]
98AFSEDGQKLITVSKDubiquitination[1]
104QKLITVSKDKAIHVLubiquitination[1]
157ICLWDQRKEGPLMDMubiquitination[1]
320SGHDQRLKFWDMAQLubiquitination[1, 2]
351PLRALSSKTWSTDDFubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity). 
Sequence Annotation
 REPEAT 36 75 WD 1.
 REPEAT 82 121 WD 2.
 REPEAT 125 163 WD 3.
 REPEAT 166 205 WD 4.
 REPEAT 208 247 WD 5.
 REPEAT 250 289 WD 6.
 REPEAT 293 332 WD 7.
 MOD_RES 14 14 Phosphoserine.
 MOD_RES 378 378 Phosphothreonine.
 MOD_RES 382 382 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; rRNA processing; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 383 AA 
Protein Sequence
MDRTCEERPA EDGSDEEDPD SMEAPTRIRD TPEDIVLEAP ASGLAFHPAR DLLAAGDVDG 60
DVFVFSYSCQ EGETKELWSS GHHLKACRAV AFSEDGQKLI TVSKDKAIHV LDVEQGQLER 120
RVSKAHGAPI NSLLLVDENV LATGDDTGGI CLWDQRKEGP LMDMRQHEEY IADMALDPAK 180
KLLLTASGDG CLGIFNIKRR RFELLSEPQS GDLTSVTLMK WGKKVACGSS EGTIYLFNWN 240
GFGATSDRFA LRAESIDCMV PVTESLLCTG STDGVIRAVN ILPNRVVGSV GQHTGEPVEE 300
LALSHCGRFL ASSGHDQRLK FWDMAQLRAV VVDDYRRRKK KGGPLRALSS KTWSTDDFFA 360
GLREEGEDSM AQEEKEETGD DSD 383 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; ISS:UniProtKB.
 GO:0006364; P:rRNA processing; ISS:UniProtKB. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom.
 IPR017422; WD_repeat_p55. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS