UniProt Accession

 EFHD2_RAT; Q4FZY0 

Genbank Protein ID

 BC098936 

Genbank Nucleotide ID

 AAH98936.1 

Protein Name

 EF-hand domain-containing protein D2 

Protein Synonyms/Alias

 Swiprosin-1 

Gene Name

 Efhd2 

Gene Synonyms/Alias

 Sws1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
9	ATDELASKLSRRLQM	acetylation	[1]
91	EFKEFSRKQIKDMEK	acetylation	[1]
94	EFSRKQIKDMEKMFK	acetylation	[1]
98	KQIKDMEKMFKQYDA	acetylation	[1]
101	KDMEKMFKQYDAGKD	acetylation	[1]
107	FKQYDAGKDGFIDLM	acetylation	[1]
158	EFLLIFRKAAAGELQ	ubiquitination	[2]
232	KQRKAAFKELQSTFK	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). Plays a role as negative regulator of the canonical NF-kappa-B-activating branch (By similarity). Controls spontaneous apoptosis through the regulation of BCL2L1 abundance (By similarity). 

Sequence Annotation

 DOMAIN 91 126 EF-hand 1.
 DOMAIN 127 162 EF-hand 2.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 11 11 Phosphoserine (By similarity).
 MOD_RES 73 73 Phosphoserine (By similarity).
 MOD_RES 75 75 Phosphoserine (By similarity).
 MOD_RES 82 82 Phosphotyrosine (By similarity).
 MOD_RES 232 232 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Calcium; Complete proteome; Direct protein sequencing; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 239 AA 

Protein Sequence

Gene Ontology

 GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; IEA:Compara. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR002048; EF_hand_dom. 

Pfam

 PF13499; EF_hand_5 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS