CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023942
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sorting nexin-8 
Protein Synonyms/Alias
  
Gene Name
 SNX8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
185SGSDVQNKLKESAQCubiquitination[1]
201GDEFLNCKLATRAKDubiquitination[1]
307DKAAQQGKQEENDVVubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network. 
Sequence Annotation
 DOMAIN 73 181 PX.
 BINDING 109 109 Phosphatidylinositol 3-phosphate (By
 BINDING 135 135 Phosphatidylinositol 3-phosphate (By
 BINDING 148 148 Phosphatidylinositol 3-phosphate (By
 MOD_RES 452 452 Phosphothreonine.
 MOD_RES 456 456 Phosphoserine.  
Keyword
 Complete proteome; Endosome; Lipid-binding; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 465 AA 
Protein Sequence
MTGRAMDPLP AAAVGAAAEA EADEEADPPA SDLPTPQAIE PQAIVQQVPA PSRMQMPQGN 60
PLLLSHTLQE LLARDTVQVE LIPEKKGLFL KHVEYEVSSQ RFKSSVYRRY NDFVVFQEML 120
LHKFPYRMVP ALPPKRMLGA DREFIEARRR ALKRFVNLVA RHPLFSEDVV LKLFLSFSGS 180
DVQNKLKESA QCVGDEFLNC KLATRAKDFL PADIQAQFAI SRELIRNIYN SFHKLRDRAE 240
RIASRAIDNA ADLLIFGKEL SAIGSDTTPL PSWAALNSST WGSLKQALKG LSVEFALLAD 300
KAAQQGKQEE NDVVEKLNLF LDLLQSYKDL CERHEKGVLH KHQRALHKYS LMKRQMMSAT 360
AQNREPESVE QLESRIVEQE NAIQTMELRN YFSLYCLHQE TQLIHVYLPL TSHILRAFVN 420
SQIQGHKEMS KVWNDLRPKL SCLFAGPHST LTPPCSPPED GLCPH 465 
Gene Ontology
 GO:0031901; C:early endosome membrane; IDA:UniProtKB.
 GO:0035091; F:phosphatidylinositol binding; IMP:UniProtKB.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0034498; P:early endosome to Golgi transport; IMP:UniProtKB.
 GO:0006886; P:intracellular protein transport; IMP:UniProtKB. 
Interpro
 IPR001683; Phox. 
Pfam
 PF00787; PX 
SMART
 SM00312; PX 
PROSITE
 PS50195; PX 
PRINTS