CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018461
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Telomeric repeat-binding factor 2-interacting protein 1 
Protein Synonyms/Alias
 TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; Repressor/activator protein 1 homolog; RAP1 homolog 
Gene Name
 Terf2ip 
Gene Synonyms/Alias
 Rap1; MNCb-0448; MNCb-0628 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
310QEVGTAIKVIRQLMEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'- TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. 
Sequence Annotation
 DOMAIN 78 101 BRCT.
 DOMAIN 125 185 Myb-like.
 MOTIF 377 393 Nuclear localization signal (Potential).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 36 36 Phosphoserine (By similarity).
 MOD_RES 151 151 Phosphoserine (By similarity).
 MOD_RES 153 153 Phosphoserine (By similarity).
 MOD_RES 200 200 Phosphoserine.  
Keyword
 Acetylation; Activator; Chromosome; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Telomere; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 393 AA 
Protein Sequence
MAEAMDLGKD PNGPTHSSTL FVREDGSAMS FYVRPSSAKR RLSTLILHGG GTVCRVQEPG 60
AVLLAQPGEA LAEASGDFIS TQYILDCVDR NEKLDLEAYR LGLTEQASDP KPGASTEGST 120
EPEPQPLTGR IAYTDAEDVA ILTYVKENAR SPSSVTGNAL WKAMEKSSLT QHSWQSLKDR 180
YLKHLRGQEH KYLLGNAPVS PSSQKLKRKA EQDPEAADSG EPQNKRAPDL PEEECVKGEI 240
KENGEADNKL FEEAAPEFGE AVVDESPDFE IHITMCDGDP PTPEEDSETQ PDEEEEEPKV 300
STQEVGTAIK VIRQLMEKFN LDLSTVTQAL LKNSGELEAT SSFLESGRRP DGYPIWCRQD 360
DLDLQKDDDD TKNALVKKFG AQNVARRIEF RKK 393 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0030870; C:Mre11 complex; IEA:Compara.
 GO:0000784; C:nuclear chromosome, telomeric region; IDA:MGI.
 GO:0000783; C:nuclear telomere cap complex; IEA:Compara.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0048239; P:negative regulation of DNA recombination at telomere; IMP:UniProtKB.
 GO:0032205; P:negative regulation of telomere maintenance; IEA:Compara.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IDA:UniProtKB.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB.
 GO:0070198; P:protein localization to chromosome, telomeric region; IEA:Compara.
 GO:0010569; P:regulation of double-strand break repair via homologous recombination; IMP:UniProtKB.
 GO:0010833; P:telomere maintenance via telomere lengthening; IMP:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR009057; Homeodomain-like.
 IPR015010; Rap1_Myb_dom. 
Pfam
 PF08914; Myb_DNA-bind_2 
SMART
  
PROSITE
 PS50172; BRCT
 PS50090; MYB_LIKE 
PRINTS