CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025664
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA replication licensing factor MCM5 
Protein Synonyms/Alias
 Minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae); Minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae), isoform CRA_a 
Gene Name
 Mcm5 
Gene Synonyms/Alias
 mCG_14998 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
350IFGGMDMKKAIACLLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Cell cycle; Cell division; Complete proteome; DNA replication; DNA-binding; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 734 AA 
Protein Sequence
MSGFDDPGIF YSDSFGGDPG AEEGQARKSQ LQRRFKEFLR QYRVGTDRTG FTFKYRDELK 60
RHYNLGEYWI EVEMEDLASF DEELADHLHK QPAEHLQLLE EAAKEVADEV TRPRPAGDEL 120
LQDIQVMLKS DASPSSIRIL KSDMMSHLVK IPGIIISASA VRAKATRISI QCRSCHNTLT 180
NIAMRPGLEG YALPRKCNMD QAGRPKCPLD PYFIMPDKCK CVDFQTLKLQ ELPDAVPHGE 240
MPRHMQLYCD RYLCDKVVPG NRVTIMGIYS IKKFGLNPSK GRDRVGVGIR SSYIRVLGIQ 300
VDTDGSGRSF AGSVSPQEEE EFRRLAALPN IYELISKSIS PSIFGGMDMK KAIACLLFGG 360
SRKRLPDGLT RRGDINLLML GDPGTAKSQL LKFVEKCSPI GVYTSGKGSS AAGLTASVIR 420
DPSSRNFIME GGAMVLADGG VVCIDEFDKM REDDRVAIHE AMEQQTISIA KAGITTTLNS 480
RCSVLAAANS VFGRWDETKG EDNIDFMPTI LSRFDMIFIV KDEHNEERDM MLAKHVMTLH 540
VSALTQTQAV EGEIDLAKMK KFIAYCRARC GPRLSAEAAE KLKNRYIIMR SGARQHERDS 600
DRRSSIPITV RQLEAIVRIA EALSKMKLQP FATEADVEEA LRLFQVSTLD AALSGNLSGV 660
EGFTTQEDQE MLSRIEKQLK RRFAIGSQVS EHSIVQDFTK QKYPEHAIRK VLQLMLRRGE 720
IQHRMQRKVL YRLK 734 
Gene Ontology
 GO:0042555; C:MCM complex; IEA:Compara.
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003678; F:DNA helicase activity; IEA:InterPro.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0032508; P:DNA duplex unwinding; IEA:GOC.
 GO:0006270; P:DNA replication initiation; IEA:InterPro. 
Interpro
 IPR008048; MCM5.
 IPR018525; MCM_CS.
 IPR001208; MCM_DNA-dep_ATPase.
 IPR012340; NA-bd_OB-fold.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00493; MCM 
SMART
 SM00350; MCM 
PROSITE
 PS00847; MCM_1
 PS50051; MCM_2 
PRINTS
 PR01657; MCMFAMILY.
 PR01661; MCMPROTEIN5.