UniProt Accession

 G3BP2_MOUSE; P97379; Q3UL55; Q9R1B8 

Genbank Protein ID

 U65313; AF145285; AK145697 

Genbank Nucleotide ID

 AAC53553.1; AAD51933.1; BAE26595.1 

Protein Name

 Ras GTPase-activating protein-binding protein 2 

Protein Synonyms/Alias

 G3BP-2; GAP SH3 domain-binding protein 2 

Gene Name

 G3bp2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
5	***MVMEKPSPLLVG	ubiquitination	[1]
25	QYYTLLNKAPEYLHR	ubiquitination	[1, 2]
107	NSGQPERKFMQTFVL	acetylation	[3]
107	NSGQPERKFMQTFVL	ubiquitination	[1, 2]
370	NTKGVGGKLPNFGFV	ubiquitination	[1]
392	VQRILIAKPIMFRGE	acetylation	[3, 4]
392	VQRILIAKPIMFRGE	succinylation	[4]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Probable scaffold protein that may be involved in mRNA transport (Potential). 

Sequence Annotation

 DOMAIN 11 133 NTF2.
 DOMAIN 331 409 RRM.
 MOD_RES 141 141 Phosphoserine (By similarity).
 MOD_RES 149 149 Phosphoserine (By similarity).
 MOD_RES 225 225 Phosphoserine.
 MOD_RES 227 227 Phosphothreonine.
 MOD_RES 457 457 Omega-N-methylated arginine (By
 MOD_RES 468 468 Omega-N-methylated arginine (By  

Keyword

 Alternative splicing; Complete proteome; Methylation; mRNA transport; Phosphoprotein; Reference proteome; RNA-binding; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 482 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; ISO:MGI. 

Interpro

 IPR002075; NTF2.
 IPR018222; Nuclear_transport_factor_2_euk.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF02136; NTF2
 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50177; NTF2_DOMAIN
 PS50102; RRM 

PRINTS