CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028947
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Copine-1 
Protein Synonyms/Alias
  
Gene Name
 Cpne1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
132TITDFLGKSDPFLEFubiquitination[1]
146FFRQGDGKWQLAYRTacetylation[2, 3, 4]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 378 AA 
Protein Sequence
MAHCVTLVQL SVSCEHLIDK DIGSKSDPLC VLLQDVGGAW AELCRTERVR NCSSPEFSKT 60
LQIEYHFETV QKLRFGIYDI DNKTPELGDD DFLGGAECSL GQIVSSQTLT LPLMLKPGKP 120
AGRGTITDFL GKSDPFLEFF RQGDGKWQLA YRTEVVKNNL NPTWKRFSVS LQHFCGGDLS 180
TPIQVRCSDY DSDGSHDLIG TFHTTLAQLQ AVPAEFECVH PEKQQRKKNY RNSGTVRVKT 240
CRVETEYSFL DYVMGGCQIN FTVGVDFTGS NGDPSSPDSL HYLSPTGVNE YLTALWSVGS 300
VVQDYDSDKL FPAFGFGAQV PPDWQVSHEF ALNFNPSNPY CAGIQGIVDA YRQALPQVRL 360
YGPTNFAPII NHVARFAA 378 
Gene Ontology
  
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR010734; Copine. 
Pfam
 PF00168; C2
 PF07002; Copine 
SMART
 SM00239; C2 
PROSITE
  
PRINTS