| Tag | Content |
|---|
| CPLM ID | CPLM-000579 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine--pyruvate aminotransferase, mitochondrial |
Protein Synonyms/Alias | SPT; Alanine--glyoxylate aminotransferase; AGT |
Gene Name | Agxt |
Gene Synonyms/Alias | Agxt1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 225 | SLISFNDKAKYKVYS | acetylation | [1] | | 308 | HLQEMGLKFFVKDPE | acetylation | [1] | | 312 | MGLKFFVKDPEIRLP | acetylation | [1] |
|
Reference | [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ. Mol Cell. 2013 Jan 10;49(1):186-99. [ PMID: 23201123] |
Functional Description | Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes) (By similarity). |
Sequence Annotation | MOTIF 412 414 Microbody targeting signal (By
BINDING 382 382 Substrate (By similarity).
MOD_RES 231 231 N6-(pyridoxal phosphate)lysine (By |
Keyword | 3D-structure; Alternative initiation; Aminotransferase; Complete proteome; Mitochondrion; Peroxisome; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 414 AA |
Protein Sequence | MGSYQLLVPP PEALSKPLSV PTRLLLGPGP SNLAPRVLAA GSLRMIGHMQ KEMLQIMEEI 60
KQGIQYVFQT RNPLTLVVSG SGHCAMETAL FNLLEPGDSF LTGTNGIWGM RAAEIADRIG 120
ARVHQMIKKP GEHYTLQEVE EGLAQHKPVL LFLVHGESST GVVQPLDGFG ELCHRYQCLL 180
LVDSVASLGG VPIYMDQQGI DIMYSSSQKV LNAPPGISLI SFNDKAKYKV YSRKTKPVSF 240
YTDITYLAKL WGCEGETRVI HHTTPVTSLY CLRESLALIA EQGLENCWRR HREATAHLHK 300
HLQEMGLKFF VKDPEIRLPT ITTVTVPAGY NWRDIVSYVL DHFSIEISGG LGPTEERVLR 360
IGLLGYNATT ENVDRVAEAL REALQHCPKN KL 392 |
Gene Ontology | GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; TAS:HGNC. GO:0005777; C:peroxisome; TAS:HGNC. GO:0008453; F:alanine-glyoxylate transaminase activity; IMP:MGI. GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. GO:0004760; F:serine-pyruvate transaminase activity; IEA:EC. GO:0046487; P:glyoxylate metabolic process; IMP:MGI. GO:0046724; P:oxalic acid secretion; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |