CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016558
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gap junction gamma-2 protein 
Protein Synonyms/Alias
 Connexin-47; Cx47; Gap junction alpha-12 protein 
Gene Name
 Gjc2 
Gene Synonyms/Alias
 Gja12 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
186KGGGGDGKTVVTPGPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems. 
Sequence Annotation
 MOD_RES 372 372 Phosphoserine.  
Keyword
 Cell junction; Cell membrane; Complete proteome; Gap junction; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 440 AA 
Protein Sequence
MTNMSWSFLT RLLEEIHNHS TFVGKVWLTV LVVFRIVLTA VGGESIYSDE QSKFTCNTRQ 60
PGCDNVCYDA FAPLSHVRFW VFQIVVISTP SVMYLGYAVH RLARASEQER RRALRRRPGT 120
RRLPRAQLPP PPPGWPDTTD LGEAEPILAL EEDEDEEPGA PEGPGEDTEE ERAEDVAAKG 180
GGGDGKTVVT PGPAGQHDGR RRIQREGLMR VYVAQLVVRA AFEVAFLVGQ YLLYGFEVPP 240
FFACSRQPCP HVVDCFVSRP TEKTVFLLVM YVVSCLCLLL NLCEMAHLGL GSAQDAVRGR 300
RGASAAGPGP TPRPPPCAFP AAAAGLACPP DYSLVVRAAE RARAHDQNLA NLALQALRDG 360
AAVAAVSADR DSPPCAGLNA TSRGAPRVGG LASGTGSATS GGTVGEQSRP GAQEQLATKP 420
RAGSEKGSTG SRDGKATVWI 440 
Gene Ontology
 GO:0005922; C:connexon complex; IEA:InterPro.
 GO:0005921; C:gap junction; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043209; C:myelin sheath; IDA:MGI.
 GO:0005243; F:gap junction channel activity; IDA:MGI.
 GO:0007267; P:cell-cell signaling; IDA:MGI.
 GO:0009636; P:response to toxic substance; IDA:MGI. 
Interpro
 IPR000500; Connexin.
 IPR019570; Connexin_CCC.
 IPR017990; Connexin_CS.
 IPR013092; Connexin_N. 
Pfam
 PF00029; Connexin
 PF10582; Connexin_CCC 
SMART
 SM00037; CNX
 SM01089; Connexin_CCC 
PROSITE
 PS00407; CONNEXINS_1
 PS00408; CONNEXINS_2 
PRINTS
 PR00206; CONNEXIN.