CPLM-003279

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-003279

UniProt Accession

ILVE_ECOLI; P0AB80; P00510; Q2M879; Q47299

Genbank Protein ID

X02413; M32253; M10313; X04890; M87049; U00096; AP009048; V00290

Genbank Nucleotide ID

CAA26262.1; AAA24022.1; AAB59052.1; CAA28575.1; AAA67573.1; AAT48207.1; BAE77527.1; CAA23559.1

Protein Name

Branched-chain-amino-acid aminotransferase

Protein Synonyms/Alias

BCAT; Transaminase B

Gene Name

ilvE

Gene Synonyms/Alias

b3770; JW5606

Created Date

July 27, 2013

Organism

Escherichia coli (strain K12)

NCBI Taxa ID

83333

Lysine Modification

Position	Peptide	Type	References
5	***MTTKKADYIWFN	acetylation	[1]
22	MVRWEDAKVHVMSHA	acetylation	[1]
47	IRCYDSHKGPVVFRH	acetylation	[1]
228	ITRDAIIKLAKELGI	acetylation	[1]
231	DAIIKLAKELGIEVR	acetylation	[1]

Reference

[1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]

Functional Description

Acts on leucine, isoleucine and valine.

Sequence Annotation

MOD_RES 160 160 N6-(pyridoxal phosphate)lysine.

Keyword

3D-structure; Amino-acid biosynthesis; Aminotransferase; Branched-chain amino acid biosynthesis; Complete proteome; Pyridoxal phosphate; Reference proteome; Transferase.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

309 AA

Protein Sequence

MTTKKADYIW FNGEMVRWED AKVHVMSHAL HYGTSVFEGI RCYDSHKGPV VFRHREHMQR 60
LHDSAKIYRF PVSQSIDELM EACRDVIRKN NLTSAYIRPL IFVGDVGMGV NPPAGYSTDV 120
IIAAFPWGAY LGAEALEQGI DAMVSSWNRA APNTIPTAAK AGGNYLSSLL VGSEARRHGY 180
QEGIALDVNG YISEGAGENL FEVKDGVLFT PPFTSSALPG ITRDAIIKLA KELGIEVREQ 240
VLSRESLYLA DEVFMSGTAA EITPVRSVDG IQVGEGRCGP VTKRIQQAFF GLFTGETEDK 300
WGWLDQVNQ 309

Gene Ontology

GO:0004084; F:branched-chain-amino-acid transaminase activity; IDA:EcoCyc.
GO:0042802; F:identical protein binding; IDA:EcoCyc.
GO:0052656; F:L-isoleucine transaminase activity; IEA:EC.
GO:0052654; F:L-leucine transaminase activity; IEA:EC.
GO:0052655; F:L-valine transaminase activity; IEA:EC.
GO:0006532; P:aspartate biosynthetic process; IGI:EcoliWiki.
GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-UniPathway.
GO:0009098; P:leucine biosynthetic process; IDA:EcoCyc.
GO:0009099; P:valine biosynthetic process; IDA:EcoCyc.

Interpro

IPR001544; Aminotrans_IV.
IPR018300; Aminotrans_IV_CS.
IPR005785; B_amino_transI.

Pfam

PF01063; Aminotran_4

SMART

PROSITE

PS00770; AA_TRANSFER_CLASS_4

PRINTS