UniProt Accession

 B2L13_HUMAN; Q9BXK5; B3KPE7; Q96B37; Q96IB7; Q9BY01; Q9HC05; Q9UFE0; Q9UKN3 

Genbank Protein ID

 AF325209; AF246665; AF183411; CR456521; AK056248; AC006285; BC007658; BC016037; AF146568; AL133029 

Genbank Nucleotide ID

 AAK27358.1; AAK15150.1; AAG09680.1; CAG30407.1; BAG51659.1; AAH07658.1; AAH16037.1; AAF03602.1; CAB61361.1 

Protein Name

 Bcl-2-like protein 13 

Protein Synonyms/Alias

 Bcl2-L-13; Bcl-rambo; Protein Mil1 

Gene Name

 BCL2L13 

Gene Synonyms/Alias

 MIL1; CD003 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
412	TETLLSEKEINAREE	ubiquitination	[1, 2]
440	PVPPSEGKSRLSPAG	ubiquitination	[2]
450	LSPAGEMKPMPLSEG	ubiquitination	[3, 4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 May promote the activation of caspase-3 and apoptosis. 

Sequence Annotation

 REPEAT 246 256 A.
 REPEAT 261 271 A; approximate.
 REPEAT 425 441 B.
 REPEAT 443 459 B; approximate.
 MOTIF 14 30 BH4.
 MOTIF 100 116 BH3.
 MOTIF 147 157 BH1.
 MOTIF 193 206 BH2.
 MOD_RES 38 38 Phosphoserine.
 MOD_RES 371 371 Phosphoserine (By similarity).
 MOD_RES 420 420 Phosphoserine.
 MOD_RES 426 426 Phosphoserine.
 MOD_RES 429 429 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; Apoptosis; Complete proteome; Membrane; Mitochondrion; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 485 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IDA:UniProtKB.
 GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; NAS:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; NAS:UniProtKB.
 GO:0006917; P:induction of apoptosis; NAS:UniProtKB. 

Interpro

 IPR002475; Bcl2-like.
 IPR026298; Blc2_fam. 

Pfam

 PF00452; Bcl-2 

SMART

  

PROSITE

 PS50062; BCL2_FAMILY
 PS01080; BH1
 PS01258; BH2
 PS01259; BH3
 PS01260; BH4_1
 PS50063; BH4_2 

PRINTS