UniProt Accession

 NC2B_HUMAN; Q01658 

Genbank Protein ID

 M97388; BT006972; AL137159; BC002809; BC035507; BC068553 

Genbank Nucleotide ID

 AAA58442.1; AAP35618.1; CAC17578.1; AAH02809.1; AAH35507.1; AAH68553.1 

Protein Name

 Protein Dr1 

Protein Synonyms/Alias

 Down-regulator of transcription 1; Negative cofactor 2-beta; NC2-beta; TATA-binding protein-associated phosphoprotein 

Gene Name

 DR1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
128	QQQELFAKARQQQAE	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. 

Sequence Annotation

 MOTIF 100 103 Nuclear localization signal (Potential).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 166 166 Phosphoserine.
 MOD_RES 167 167 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 176 AA 

Protein Sequence

Gene Ontology

 GO:0005671; C:Ada2/Gcn5/Ada3 transcription activator complex; IDA:BHF-UCL.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0017025; F:TBP-class protein binding; IDA:BHF-UCL.
 GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
 GO:0043966; P:histone H3 acetylation; IDA:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR003958; CBFA_NFYB_domain.
 IPR027113; Dr1/Ncb2.
 IPR009072; Histone-fold.
 IPR003957; Transcrpt_fac_CBFA/NFYB_topo. 

Pfam

 PF00808; CBFD_NFYB_HMF 

SMART

  

PROSITE

  

PRINTS

 PR00615; CCAATSUBUNTA.