CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012337
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative heat shock protein HSP 90-alpha A2 
Protein Synonyms/Alias
 Heat shock 90 kDa protein 1 alpha-like 3 
Gene Name
 HSP90AA2 
Gene Synonyms/Alias
 HSPCAL3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
74PSKLDSGKELHINLIubiquitination[1]
112NNLGTIAKSGTKAFMubiquitination[1]
185ERMGRGTKVILHLKEubiquitination[1]
282KKKKTKEKYIDQEELubiquitination[1]
291IDQEELNKTKPIWTRubiquitination[1]
293QEELNKTKPIWTRNPubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins (By similarity). 
Sequence Annotation
 BINDING 51 51 ATP (By similarity).
 BINDING 93 93 ATP (By similarity).
 BINDING 112 112 ATP (By similarity).
 BINDING 138 138 ATP; via amide nitrogen (By similarity).
 MOD_RES 263 263 Phosphoserine.  
Keyword
 ATP-binding; Chaperone; Complete proteome; Cytoplasm; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 343 AA 
Protein Sequence
MPEETQTQDQ PMEEEEVETF AFQAEIAQLM SLIINTFYSN KEIFLRELIS NSSDALDKIW 60
YESLTDPSKL DSGKELHINL IPNKQDQTLT IVDTGIGMTK ADLINNLGTI AKSGTKAFME 120
ALQAGADISM IGQFGVSFYS AYLVAEKVTV ITKHNDDEQY AWESSAGGSF TVRTDTGERM 180
GRGTKVILHL KEDQTEYLEE QRIKEIVKKH SQLIGYPITL FVEKECDKEV SDDETEEKED 240
KEEEKEKEEK ESKDKPEIED VGSDEEEEKK DGDKKKKKTK EKYIDQEELN KTKPIWTRNP 300
DDITNEEYGE FCKNLTNDWE DHLAVKHFSV EGQLEFRALL FVP 343 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 
Interpro
 IPR003594; HATPase_ATP-bd.
 IPR019805; Heat_shock_protein_90_CS.
 IPR001404; Hsp90.
 IPR020575; Hsp90_N.
 IPR020568; Ribosomal_S5_D2-typ_fold. 
Pfam
 PF02518; HATPase_c
 PF00183; HSP90 
SMART
 SM00387; HATPase_c 
PROSITE
 PS00298; HSP90 
PRINTS
 PR00775; HEATSHOCK90.