CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012870
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytoplasmic tRNA 2-thiolation protein 2 
Protein Synonyms/Alias
  
Gene Name
 CTU2 
Gene Synonyms/Alias
 C16orf84; NCS2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
151SVRTLTAKEELLQTLubiquitination[1]
248FTPAVDTKAPEKASIubiquitination[1]
384YSCRVNMKDLPSLDPubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. 
Sequence Annotation
 MOD_RES 2 2 N-acetylcysteine.
 MOD_RES 415 415 Phosphoserine.
 MOD_RES 419 419 Phosphoserine.
 MOD_RES 508 508 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome; tRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 515 AA 
Protein Sequence
MVWQVLEGLS QDSAKRLRFV AGVIFVDEGA ACGQSLEERS KTLAEVKPIL QATGFPWHVV 60
ALEEVFSLPP SVLWCSAQEL VGSEGAYKAA VDSFLQQQHV LGAGGGPGPT QGEEQPPQPP 120
LDPQNLARPP APAQTEALSQ LFCSVRTLTA KEELLQTLRT HLILHMARAH GYSKVMTGDS 180
CTRLAIKLMT NLALGRGAFL AWDTGFSDER HGDVVVVRPM RDHTLKEVAF YNRLFSVPSV 240
FTPAVDTKAP EKASIHRLME AFILRLQTQF PSTVSTVYRT SEKLVKGPRD GPAAGDSGPR 300
CLLCMCALDV DAADSATAFG AQTSSRLSQM QSPIPLTETR TPPGPCCSPG VGWAQRCGQG 360
ACRREDPQAC IEEQLCYSCR VNMKDLPSLD PLPPYILAEA QLRTQRAWGL QEIRDCLIED 420
SDDEAGQS 428 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0043234; C:protein complex; IDA:UniProtKB.
 GO:0034227; P:tRNA thio-modification; NAS:UniProtKB.
 GO:0002098; P:tRNA wobble uridine modification; NAS:UniProtKB. 
Interpro
 IPR019407; Thiouridylase_cyt_su2. 
Pfam
 PF10288; DUF2392 
SMART
  
PROSITE
  
PRINTS