UniProt Accession

 Q8CAR0_MOUSE; Q8CAR0 

Genbank Protein ID

 AC125082; AC139754; AK038119 

Genbank Nucleotide ID

 BAC29934.1 

Protein Name

 Insulin-like growth factor I 

Protein Synonyms/Alias

  

Gene Name

 Igf1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
59	PRGFYFNKPTGYGSS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome; Secreted. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 165 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IDA:MGI.
 GO:0001974; P:blood vessel remodeling; IMP:MGI.
 GO:0035630; P:bone mineralization involved in bone maturation; IEA:Compara.
 GO:0048754; P:branching morphogenesis of an epithelial tube; IMP:MGI.
 GO:0048468; P:cell development; IMP:MGI.
 GO:0050650; P:chondroitin sulfate proteoglycan biosynthetic process; IDA:MGI.
 GO:0031017; P:exocrine pancreas development; IMP:MGI.
 GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IDA:MGI.
 GO:0010001; P:glial cell differentiation; IMP:MGI.
 GO:0048839; P:inner ear development; IDA:MGI.
 GO:0048009; P:insulin-like growth factor receptor signaling pathway; IDA:MGI.
 GO:0048286; P:lung alveolus development; IMP:MGI.
 GO:0060463; P:lung lobe morphogenesis; IMP:MGI.
 GO:0060426; P:lung vasculature development; IMP:MGI.
 GO:0030879; P:mammary gland development; IMP:MGI.
 GO:0035264; P:multicellular organism growth; IDA:MGI.
 GO:0014896; P:muscle hypertrophy; IEA:Compara.
 GO:0045445; P:myoblast differentiation; IEA:Compara.
 GO:0051450; P:myoblast proliferation; IEA:Compara.
 GO:0014904; P:myotube cell development; IEA:Compara.
 GO:0060766; P:negative regulation of androgen receptor signaling pathway; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
 GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IGI:MGI.
 GO:0034392; P:negative regulation of smooth muscle cell apoptotic process; IEA:Compara.
 GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:Compara.
 GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Compara.
 GO:0070886; P:positive regulation of calcineurin-NFAT signaling cascade; IEA:Compara.
 GO:0010613; P:positive regulation of cardiac muscle hypertrophy; IEA:Compara.
 GO:0021940; P:positive regulation of cerebellar granule cell precursor proliferation; IDA:MGI.
 GO:0043388; P:positive regulation of DNA binding; IEA:Compara.
 GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Compara.
 GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Compara.
 GO:0046326; P:positive regulation of glucose import; IEA:Compara.
 GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Compara.
 GO:0045821; P:positive regulation of glycolysis; IEA:Compara.
 GO:0043568; P:positive regulation of insulin-like growth factor receptor signaling pathway; IEA:Compara.
 GO:0043410; P:positive regulation of MAPK cascade; IEA:Compara.
 GO:0045840; P:positive regulation of mitosis; IEA:Compara.
 GO:2000288; P:positive regulation of myoblast proliferation; IMP:MGI.
 GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Compara.
 GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IEA:Compara.
 GO:0033160; P:positive regulation of protein import into nucleus, translocation; IEA:Compara.
 GO:0051897; P:positive regulation of protein kinase B signaling cascade; IDA:MGI.
 GO:0046579; P:positive regulation of Ras protein signal transduction; IEA:Compara.
 GO:0014911; P:positive regulation of smooth muscle cell migration; IEA:Compara.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein; IEA:Compara.
 GO:0060527; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; IMP:MGI.
 GO:0060736; P:prostate gland growth; IDA:MGI.
 GO:0060741; P:prostate gland stromal morphogenesis; IMP:MGI.
 GO:0032878; P:regulation of establishment or maintenance of cell polarity; IDA:MGI.
 GO:0040014; P:regulation of multicellular organism growth; IEA:Compara.
 GO:0001932; P:regulation of protein phosphorylation; IDA:MGI.
 GO:0014834; P:satellite cell maintenance involved in skeletal muscle regeneration; IEA:Compara.
 GO:0060509; P:Type I pneumocyte differentiation; IMP:MGI.
 GO:0060510; P:Type II pneumocyte differentiation; IMP:MGI.
 GO:0030104; P:water homeostasis; IGI:MGI. 

Interpro

 IPR022341; IGF-I.
 IPR016179; Insulin-like.
 IPR022350; Insulin-like_growth_factor.
 IPR022353; Insulin_CS.
 IPR022352; Insulin_family. 

Pfam

 PF00049; Insulin 

SMART

 SM00078; IlGF 

PROSITE

 PS00262; INSULIN 

PRINTS

 PR02002; INSLNLIKEGF.
 PR02005; INSLNLIKEGF1.
 PR00276; INSULINFAMLY.