UniProt Accession

 TOM20_HUMAN; Q15388; A8K195; Q498B3; Q6IBT4 

Genbank Protein ID

 AF126962; AF126958; AF126959; AF126960; AF126961; D13641; AK289810; CR456718; AL732292; CH471098; BC000882; BC066335; BC071994; BC100286; BC107851 

Genbank Nucleotide ID

 AAF13354.1; AAF13354.1; AAF13354.1; AAF13354.1; AAF13354.1; BAA02804.1; BAF82499.1; CAG32999.1; CAI21937.1; EAW70003.1; AAH00882.1; AAH66335.1; AAH71994.1; AAI00287.1; AAI07852.1 

Protein Name

 Mitochondrial import receptor subunit TOM20 homolog 

Protein Synonyms/Alias

 Mitochondrial 20 kDa outer membrane protein; Outer mitochondrial membrane receptor Tom20 

Gene Name

 TOMM20 

Gene Synonyms/Alias

 KIAA0016 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
35	RRSDPNFKNRLRERR	ubiquitination	[1, 2]
56	KERAGLSKLPDLKDA	ubiquitination	[1, 3, 4, 5, 6]
61	LSKLPDLKDAEAVQK	ubiquitination	[1, 4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). 

Sequence Annotation

 MOD_RES 135 135 Phosphoserine.
 MOD_RES 138 138 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 145 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005742; C:mitochondrial outer membrane translocase complex; NAS:UniProtKB.
 GO:0015450; F:P-P-bond-hydrolysis-driven protein transmembrane transporter activity; IDA:HGNC.
 GO:0051082; F:unfolded protein binding; IDA:HGNC.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0006626; P:protein targeting to mitochondrion; IDA:HGNC. 

Interpro

 IPR002056; MAS20_rcpt-related.
 IPR022422; MAS20_rcpt_metazoan.
 IPR023392; Tom20_dom. 

Pfam

 PF02064; MAS20 

SMART

  

PROSITE

  

PRINTS

 PR01989; EUOM20RECPTR.
 PR00351; OM20RECEPTOR.