CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022760
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pendrin 
Protein Synonyms/Alias
 Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4 
Gene Name
 Slc26a4 
Gene Synonyms/Alias
 Pds 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
537YKSITHYKNLEEPEGubiquitination[1]
601KGQLRATKNGIISDIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Sodium-independent transporter of chloride and iodide. 
Sequence Annotation
 DOMAIN 535 729 STAS.  
Keyword
 Chloride; Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 780 AA 
Protein Sequence
MAARGGRSEP PQLAEYSCSY TVSRPVYSEL AFQQQRERRL PERRTLRDSL ARSCSCSRKR 60
AFGVVKTLLP ILDWLPKYRV KEWLLSDIIS GVSTGLVGTL QGMAYALLAA VPVQFGLYSA 120
FFPILTYFVF GTSRHISVGP FPVVSLMVGS VVLSMAPDDH FLVPSGNGSA LNSTTLDTGT 180
RDAARVLLAS TLTLLVGIIQ LVFGGLQIGF IVRYLADPLV GGFTTAAAFQ VLVSQLKIVL 240
NVSTKNYNGI LSIIYTLIEI FQNIGDTNIA DFIAGLLTII VCMAVKELND RFKHRIPVPI 300
PIEVIVTIIA TAISYGANLE KNYNAGIVKS IPSGFLPPVL PSVGLFSDML AASFSIAVVA 360
YAIAVSVGKV YATKHDYVID GNQEFIAFGI SNVFSGFFSC FVATTALSRT AVQESTGGKT 420
QVAGLISAVI VMVAIVALGR LLEPLQKSVL AAVVIANLKG MFMQVCDVPR LWKQNKTDAV 480
IWVFTCIMSI ILGLDLGLLA GLLFALLTVV LRVQFPSWNG LGSVPSTDIY KSITHYKNLE 540
EPEGVKILRF SSPIFYGNVD GFKKCINSTV GFDAIRVYNK RLKALRRIQK LIKKGQLRAT 600
KNGIISDIGS SNNAFEPDED VEEPEELNIP TKEIEIQVDW NSELPVKVNV PKVPIHSLVL 660
DCGAVSFLDV VGVRSLRMIV KEFQRIDVNV YFALLQDDVL EKMEQCGFFD DNIRKDRFFL 720
TVHDAILHLQ NQVKSREGQD SLLETVARIR DCKDPLDLME AEMNAEELDV QDEAMRRLAS 780 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:UniProtKB.
 GO:0031526; C:brush border membrane; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008509; F:anion transmembrane transporter activity; ISS:MGI.
 GO:0015108; F:chloride transmembrane transporter activity; IEA:Compara.
 GO:0015111; F:iodide transmembrane transporter activity; IEA:Compara.
 GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
 GO:0009887; P:organ morphogenesis; ISS:MGI.
 GO:0006885; P:regulation of pH; IMP:UniProtKB.
 GO:0032880; P:regulation of protein localization; IMP:UniProtKB.
 GO:0008272; P:sulfate transport; IEA:InterPro. 
Interpro
 IPR018045; S04_transporter_CS.
 IPR002645; STAS_dom.
 IPR001902; SulP_transpt.
 IPR011547; Sulph_transpt. 
Pfam
 PF01740; STAS
 PF00916; Sulfate_transp 
SMART
  
PROSITE
 PS01130; SLC26A
 PS50801; STAS 
PRINTS