| Tag | Content |
|---|
| CPLM ID | CPLM-009996 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DNA-directed RNA polymerase I subunit RPA2 |
Protein Synonyms/Alias | RNA polymerase I subunit 2; DNA-directed RNA polymerase I 135 kDa polypeptide; RPA135 |
Gene Name | Polr1b |
Gene Synonyms/Alias | Rpa2; Rpo1-2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 693 | MYQCQMGKQTMGFPL | ubiquitination | [1] | | 784 | EFIDLSEKFKQGEDN | ubiquitination | [1] | | 882 | RNPTIGDKFASRHGQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). |
Sequence Annotation | ZN_FING 1070 1101 C4-type (Potential). |
Keyword | Complete proteome; DNA-directed RNA polymerase; Metal-binding; Nucleotidyltransferase; Nucleus; Reference proteome; Transcription; Transferase; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1135 AA |
Protein Sequence | MDVDGRWRNL PSGPSLKHLT DPSYGIPPEQ QKAALQDLTR AHVDSFNYAA LEGLSHAVQA 60
IPPFEFAFKD ERISLTIVDA VISPPSVPKG TICKDLNVYP AECRGRKSTY RGRLTADISW 120
AVNGVPKGII KQFLGYVPIM VKSKLCNLYN LPPRVLIEHH EEAEEMGGYF IINGIEKVIR 180
MLIVPRRNFP IAMVRPKWKS RGLGYTQFGV SMRCVREEHS AVNMNLHYVE NGTVMLNFIY 240
RKELFFLPLG FALKALVSFS DYQIFQELIK GKEEDSFFRN SVSQMLRIVI EEGCHSQKQV 300
LNYLGECFRV KLSLPDWYPN VEAAEFLLNQ CICIHLQSNT DKFYLLCLMT RKLFALARGE 360
CMDDNPDSLV NQEVLSPGQL FLMFLKEKME NWLVSIKIVL DKRAQKANVS INNENLMKIF 420
SMGTELTRPF EYLLATGNLR SKTGLGFLQD SGLCVVADKL NFLRYLSHFR CVHRGAAFAK 480
MRTTTVRRLL PESWGFLCPV HTPDGAPCGL LNHLTAVCEV VTKFVYTASI PALLCGLGVT 540
PVDTAPCRPY SDCYPVLLDG VMVGWVDKDL APEVADTLRR FKVLREKRIP PWMEVALIPM 600
TGKPSLYPGL FLFTTPCRLV RPVQNLELGR EELIGTMEQL FMNVAIFEDE VFGGISTHQE 660
LFPHSLLSVI ANFIPFSDHN QSPRNMYQCQ MGKQTMGFPL LTYQNRSDNK LYRLQTPQSP 720
LVRPCMYDFY DMDNYPIGTN AIVAVISYTG YDMEDAMIVN KASWERGFAH GSVYKSEFID 780
LSEKFKQGED NLVFGVKPGD PRVMQKLDDD GLPFIGAKLE YGDPYYSYLN LNTGEGFVVY 840
YKSKENCVVD NIKVCSNDMG SGKFKCICIT VRIPRNPTIG DKFASRHGQK GILSRLWPAE 900
DMPFTESGMM PDILFNPHGF PSRMTIGMLI ESMAGKSAAL HGLCHDATPF IFSEENSALE 960
YFGEMLKAAG YNFYGTERLY SGISGMELEA DIFIGVVYYQ RLRHMVSDKF QVRTTGARDK 1020
VTNQPLGGRN VQGGIRFGEM ERDALLAHGT SFLLHDRLFN CSDRSVAHMC VECGSLLSPL 1080
LEKPPPSWSA MRNRKYNCTV CGRSDTIDTV SVPYVFRYFV AELAAMNIKV KLDVI 1135 |
Gene Ontology | |
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Pfam | |
SMART | |
PROSITE | |
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